51047-61-1

Basic information

• Product Name: 2-(piperazin-1-yl)quinazoline
• Synonyms: 2-(piperazin-1-yl)quinazoline;1-(2-Quinazolinyl)piperazine;2-(1-Piperazinyl)quinazoline
• CAS NO: 51047-61-1
• Molecular Formula: C₁₂H₁₄N₄
• Molecular Weight: 214.26636
• Mol File: 51047-61-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 416.5±55.0 °C(Predicted)
• Appearance: /
• Density: 1.201
• PKA: 8.68±0.10(Predicted)
• CAS DataBase Reference: 2-(piperazin-1-yl)quinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(piperazin-1-yl)quinazoline(51047-61-1)
• EPA Substance Registry System: 2-(piperazin-1-yl)quinazoline(51047-61-1)

Safety Data

• Hazardous Substances Data: 51047-61-1(Hazardous Substances Data)

Usage

General Description

2-(piperazin-1-yl)quinazoline is a chemical compound with a molecular formula C14H16N4 that belongs to the quinazoline class of organic compounds. It consists of a quinazoline core with a piperazine substituent at the 2-position, resulting in a heterocyclic structure. 2-(piperazin-1-yl)quinazoline is primarily used in scientific research and drug development, particularly in the field of medicinal chemistry. It has been studied for its potential pharmacological properties, including its ability to interact with various biological targets and its potential use in the treatment of certain diseases. Additionally, 2-(piperazin-1-yl)quinazoline derivatives have been investigated for their potential antipsychotic, antimicrobial, and anticancer activities. Overall, this compound and its derivatives hold promise for a wide range of therapeutic applications and continue to be the subject of ongoing research and development efforts.

Upstream product

• 110-85-0 piperazine 
• 6141-13-5 2-chloroquinazoline 

Downstream Products

• 348134-15-6 9-[4-(4-quinazolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-4-fluoro-benzylamide 
• 348134-30-5 9-[4-(4-quinazolin-2-yl-piperazin-1-yl)-butyl]-9H-fluorene-9-carboxylic Acid-4-methoxy-benzylamide 

Relevant articles and documents

1-(2-NAPHTHYL) AND 1-(2-AZANAPHTHYL)-4-(1-PHENYLMETHYL)PIPERAZINES BEING DOPAMINE D 4? RECEPTOR SUBTYPE LIGANDS

Disclosed are compounds of formula: (I) or pharmaceutically acceptable addition salts thereof, wherein: X, Y and Z are the same or different and represent optionally substituted carbon or nitrogen; R1 and R2 independently represent organic or inorganic substituents; R3 and R4 are variables independently representing inorganic or organic substituents; A represents C1-C4 alkylene; and R5, R6 and R7 independently represent hydrogen or C1-C6 alkyl, which compounds bind selectively with high affinity to the dopamine D4 receptor subtype and are therefore of use in treatment of various neuropsychological disorders.

2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine D4 receptor subtype ligands

Disclosed are compounds of the formula: or the pharmaceutically acceptable acid addition salts thereof wherein: Ra represents where X, Y and Z are the same or different and represent CH or nitrogen; R1 R2, R3 and R4 independently represent organic or inorganic groups; and R5 is hydrogen, C1-C6 alkyl or halogen, which compounds are useful for the treatment and/or prevention of neuropsychological disorders including, but not limited to, schizophrenia, mania, dementia, depression, anxiety, compulsive behavior, substance abuse, Parkinson-like motor disorders and motion disorders related to the use of neuroleptic agents.