51084-83-4

Basic information

• Product Name: 2-AMINO-1-(3-CHLORO-PHENYL)-ETHANONE HYDROCHLORIDE
• Synonyms: 2-AMINO-1-(3-CHLORO-PHENYL)-ETHANONE HYDROCHLORIDE;2-AMINO-3'-CHLOROACETOPHENONE HYDROCHLORIDE;3-CHLOROPHENACYLAMINE HYDROCHLORIDE;2-Amino-3'-chloroacetophenone hydrochloride, 2-Amino-1-(3-chlorophenyl)ethan-1-one hydrochloride;2-aMino-1-(3-chlorophenyl)ethan-1-one hydrochloride;2-AMino-3'-chloroacetophenone HCl;Ethanone, 2-amino-1-(3-chlorophenyl)-, hydrochloride (1:1)
• CAS NO: 51084-83-4
• Molecular Formula: C₈H₈ClNO*ClH
• Molecular Weight: 206.07
• Mol File: 51084-83-4.mol
• Article Data: 10

Chemical Properties

• Melting Point: 222 °C
• Appearance: /
• CAS DataBase Reference: 2-AMINO-1-(3-CHLORO-PHENYL)-ETHANONE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-1-(3-CHLORO-PHENYL)-ETHANONE HYDROCHLORIDE(51084-83-4)
• EPA Substance Registry System: 2-AMINO-1-(3-CHLORO-PHENYL)-ETHANONE HYDROCHLORIDE(51084-83-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 51084-83-4(Hazardous Substances Data)

Usage

General Description

2-AMINO-1-(3-CHLORO-PHENYL)-ETHANONE HYDROCHLORIDE is a chemical compound with the molecular formula C8H10ClNO.HCl. It is a hydrochloride salt of 2-amino-1-(3-chloro-phenyl)-ethanone, which is a derivative of acetophenone. 2-AMINO-1-(3-CHLORO-PHENYL)-ETHANONE HYDROCHLORIDE is used in the production of pharmaceuticals and agrochemicals as a building block for the synthesis of various compounds. It is also used as a reagent in organic synthesis and as a research chemical in the field of medicinal chemistry. The hydrochloride salt form of this compound makes it more stable and suitable for use in different applications.

Upstream product

• 93103-01-6 2-Amino-3-(3-chloro-phenyl)-3-oxo-propionic acid methyl ester; hydrochloride 
• 1029539-01-2 Br^(1-)*C₁₄H₁₈ClN₄O⁽¹⁺⁾ 
• 41011-01-2 2-bromo-1-(3-chloro-phenyl)-ethanone 
• 99-02-5 3'-Chloroacetophenone 

Downstream Products

• 93103-17-4 4-(3-Chloro-phenyl)-1H-imidazole-2-thiol 
• 105336-08-1 N-[2-(3-Chloro-phenyl)-2-oxo-ethyl]-2-[(Z)-2,4-dioxo-imidazolidin-1-ylimino]-acetamide 
• 166312-60-3 3-chloro-α-benzoylaminoacetophenone 
• 1192424-47-7 C₁₉H₂₆ClN₃O₂S 
• 1192424-45-5 C₁₉H₂₇ClN₂O₄S 

Relevant articles and documents

Design, synthesis and evaluation of novel 5-phenylthiophene derivatives as potent fungicidal of Candida albicans and antifungal reagents of fluconazole-resistant fungi

A series of 5-phenylthiophene derivatives with novel structures were designed and synthesized to combat the increasing incidence of susceptible and drug-resistant fungal infections. The antifungal activity of the synthesized compounds was assessed against seven susceptible strains and six fluconazole-resistant strains. It is especially encouraging that compounds 17b and 17f displayed significant antifungal activities against all tested strains. Furthermore, the potent compounds 17b and 17f could prevent the formation of fungi biofilms and 17f displayed satisfactory fungicidal activity. Preliminary mechanistic studies showed that the potent antifungal activity of compound 17f stemmed from inhibition of C. albicans CYP51. In addition, Compounds 17b and 17f were almost nontoxic to mammalian A549, MCF-7, and THLE-2 cells. These results strongly suggested that compounds 17b and 17f are promising as novel antifungal drugs.

AMINOPYRIDINE DERIVATIVES AS TAM FAMILY KINASE INHIBITORS

Provided herein are aminopyridine derivatives and pharmaceutical compositions that are useful as TAM family kinase inhibitors.

COMPOUNDS HAVING NPY Y5 RECEPTOR ANTAGONISTIC ACTIVITY

This invention provides a compound of the formula (I): a pharmaceutically acceptable salt or solvate thereof, wherein R1 is substituted or unsubstituted alkyl or the like, R2 is hydrogen or substituted or unsubstituted alkyl, Ring A is monocyclic or bicyclic aromatic heterocycle, R3 is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl or substituted or unsubstituted heterocycle, R4 is halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl or the like, m is an integer between 0 and 2, n is an integer between 0 and 5, R is halogen, oxo, cyano, nitro, substituted or unsubstituted alkyl or the like, and p is an integer between 0 and 2 as novel compounds having NPY Y5 antagonistic activity.