51085-92-8

Basic information

• Product Name: 6-CHLOROCHROMONE-3-CARBOXYLIC ACID
• Synonyms: TIMTEC-BB SBB005419;RARECHEM AL BO 1383;6-CHLORO-4-OXO-4H-CHROMENE-3-CARBOXYLIC ACID;6-CHLOROCHROMONE-3-CARBOXYLIC ACID
• CAS NO: 51085-92-8
• Molecular Formula: C₁₀H₅ClO₄
• Molecular Weight: 224.6
• Mol File: 51085-92-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-CHLOROCHROMONE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLOROCHROMONE-3-CARBOXYLIC ACID(51085-92-8)
• EPA Substance Registry System: 6-CHLOROCHROMONE-3-CARBOXYLIC ACID(51085-92-8)

Safety Data

• Hazardous Substances Data: 51085-92-8(Hazardous Substances Data)

Usage

General Description

6-Chlorochromone-3-carboxylic acid is a chemical compound with the molecular formula C10H5ClO4. It is derived from chromone, a heterocyclic compound containing oxygen and benzopyran ring structures. 6-CHLOROCHROMONE-3-CARBOXYLIC ACID contains a chloro group and a carboxylic acid group, making it useful in the synthesis of other organic compounds. It has potential applications in the pharmaceutical and chemical industries, including in the production of pharmaceutical drugs and agrochemicals. 6-CHLOROCHROMONE-3-CARBOXYLIC ACID may also have biological activity and could be investigated for its potential therapeutic properties.

Upstream product

• 42248-31-7 6-Chloro-4-oxo-4H-chromene-3-carbaldehyde 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 

Downstream Products

• 68723-76-2 8-chloro-2-phenyl-2H-chromeno[4,3-c]pyrazol-3-one 
• 80031-01-2 (E)-1-(5-Chloro-2-hydroxy-phenyl)-3-piperidin-1-yl-propenone 
• 113018-98-7 6-Chloro-4-hydroxy-2-oxo-2H-chromene-3-carbaldehyde 
• 33533-99-2 6-chloro-4H-chromen-4-one 
• 1450-74-4 5-chloro-2-hydroxyacetophenone 
• 91998-75-3 6-Chloro-2-hydroxy-chroman-4-one 

Relevant articles and documents

Synthesis and biological evaluation of chromone-3-carboxamides

The aim of our study was to synthesize novel chromone-3-carboxamides and to conduct biological evaluations in search for lead compounds for the treatment of a range of debilitating disease states. Corresponding 2-hydroxyacetophenones were subjected to Vilsmeier-Haack formylation to give chromone-3-carbaldehydes, which were subsequently oxidised to give chromone-3-carboxylic acids. Treatment of the carboxylic acids with thionyl chloride resulted in the in situ formation of the corresponding acid chlorides, which were reacted with various amines in the presence of triethylamine to give the corresponding novel chromone-3-carboxamides in good yields. Selected chromone derivatives were then evaluated for their anti-inflammatory, anti-tryponosomal and cytotoxic properties.

Synthesis of imidazolidines, saccharins and chromone bearing imidazolidine ring

As a part of a research program related to the synthetic study of pharmacologically and agrochemically interesting imidazolidines, we synthesized imidazolidines 8, 9, 10, saccharins 12, 13 and chromone 17 bearing imidazolidine-2,4,5-trione or 2-thioxoimodazolidine-4,5-dione rings.

Kinetics and mechanism of hydrogen peroxide oxidation of chromone-3-carboxaldehydes in aqueous acid and micellar media

Oxidation of chromone-3-carboxaldehyde (CCA) and substituted analogues by H2O2 has been carried out in aqueous acid (HCl and H2SO4) and micellar media. Reaction kinetics indicated order in |CCA| as well as |H2O2| to be unity while it is a fraction (1 > n > O) in |acid|. Reaction rates were found to be faster in the solvents of low-dielectric constant (D). Added salt (KCl or (NH4)2SO4) increased the rate of oxidation marginally. On the basis of observed linearity of Amis plot and marginal positive salt effect, protonated CCA (enol form of CCA, a cation) and H2O2 (neutral molecule) were considered as reactive species in the rate limiting step. Reaction rates were found to be enhanced significantly in anionic and nonionic micellar (sodium dodecylsulfate (SDS) and Triton X-100 (Tx), respectively) media. However, cationic micelles [cetyl trimethyl ammonium bromide (CTAB)| indicated marginal retardation effect. Effect of anionic and cationic micelles has been interpreted in terms of electrostatic interactions, while that of nonionic micelles in terms of hydrophobic interactions. Structure-reactivity correlations have been interpreted by Hammett's equation. Negative "p" (reaction constant) values indicated cationic transition state. 1996 John Wiley &Sons, Inc.