51094-28-1

Basic information

• Product Name: 9H-CARBAZOLE-2-CARBOXYLIC ACID
• Synonyms: 9H-CARBAZOLE-2-CARBOXYLIC ACID
• CAS NO: 51094-28-1
• Molecular Formula: C₁₃H₉NO₂
• Molecular Weight: 211.21606
• Mol File: 51094-28-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9H-CARBAZOLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 9H-CARBAZOLE-2-CARBOXYLIC ACID(51094-28-1)
• EPA Substance Registry System: 9H-CARBAZOLE-2-CARBOXYLIC ACID(51094-28-1)

Safety Data

• Hazardous Substances Data: 51094-28-1(Hazardous Substances Data)

Usage

General Description

9H-Carbazole-2-carboxylic acid is a chemical compound with a molecular formula of C14H9NO2. It is a derivative of carbazole, a heterocyclic compound that is commonly found in coal tar and crude oil. 9H-Carbazole-2-carboxylic acid is a white to pale yellow crystalline powder that is insoluble in water but soluble in organic solvents. It is used in the synthesis of various pharmaceuticals and dyes, as well as in the production of electronic materials and organic semiconductors. The compound has also been studied for its potential biological activities, including its anti-inflammatory and anticancer properties.

Upstream product

• 57955-18-7 9H-carbazole-2-carbonitrile 
• 23592-74-7 2-acetylcarbazole 
• 26000-33-9 methyl 9H-carbazole-2-carboxylate 
• 92161-43-8 1-(9H-carbazol-2-yl)-2-chloro-1-ethanone 
• 912764-83-1 1-carbazol-2-yl-2-phenyl-ethanone 
• 88092-92-6 9-acetyl-2-(chloroacetyl)carbazole 
• 86-74-8 9H-carbazole 
• 15719-64-9 methylammonium carbonate 
• 124-38-9 carbon dioxide 
• 99847-12-8 2-nitro-[1, 1’-biphenyl]-4-carboxylic acid 
• 574-39-0 9-acetylcarbazole 
• 19264-68-7 9-benzoyl-9H-carbazole 
• 92247-98-8 5,6,7,8-tetrahydro-carbazole-2-carboxylic acid methyl ester 
• 700863-88-3 1-(9-benzoyl-carbazol-2-yl)-2-phenyl-ethanone 

Downstream Products

• 1361925-34-9 N-benzylcarbazole-2-carboxamide 
• 4539-51-9 2-aminocarbazole 
• 2036044-77-4 N-((3-fluoro-2'-methyl-[2,4'-bipyridin]-5-yl)methyl)-9H-carbazole-2-carboxamide 

Relevant articles and documents

Design, synthesis, and evaluation of potent Wnt signaling inhibitors featuring a fused 3-ring system

The Wnt signaling pathway is a critical developmental pathway which operates through control of cellular functions such as proliferation and differentiation. Aberrant Wnt signaling has been linked to the formation and metastasis of tumors. Porcupine, a member of the membrane-bound O-acyltransferase family of proteins, is an important component of the Wnt pathway. Porcupine catalyzes the palmitoylation of Wnt proteins, a process needed for their secretion and activity. Here we report a novel series of compounds obtained by a scaffold hybridization strategy from a known porcupine inhibitor class. The leading compound 59 demonstrated subnanomolar inhibition of Wnt signaling in a paracrine cellular assay. Compound 59 also showed excellent chemical, plasma and liver microsomal stabilities. Furthermore, compound 59 exhibited good pharmacokinetic profiles with 30% oral bioavailability in rat. Collectively, these results strongly support further optimization of this novel scaffold to develop better Wnt pathway inhibitors.

FUNCTIONALISED AND SUBSTITUTED CARBAZOLES AS ANTI-CANCER AGENTS

The present invention relates to anti-tropomyosin compounds, processes for their preparation, and methods for treating or preventing a disease or disorder, such as a proliferative disease (preferably cancer), using compounds of the invention.

Dioxomolybdenum(VI)-catalyzed reductive cyclization of nitroaromatics. Synthesis of carbazoles and indoles

Reductive cyclization of nitrobiphenyls and nitrostyrenes to carbazoles and indoles, respectively, is carried out by triphenylphosphine under mild conditions catalyzed by a dichlorodioxomolybdenum(VI) complex. A one-pot procedure for the synthesis of regioselectively functionalized indoles has been developed from commercially available onitrobenzaldehydes and phosphoranes.