51131-78-3

Basic information

• Product Name: Guanidine, N,N'-bis(3-methylphenyl)-
• CAS NO: 51131-78-3
• Molecular Formula: C15H17N3
• Molecular Weight: 239.32
• Mol File: 51131-78-3.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Guanidine, N,N'-bis(3-methylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Guanidine, N,N'-bis(3-methylphenyl)-(51131-78-3)
• EPA Substance Registry System: Guanidine, N,N'-bis(3-methylphenyl)-(51131-78-3)

Safety Data

• Hazardous Substances Data: 51131-78-3(Hazardous Substances Data)

Upstream product

• 108-44-1 1-amino-3-methylbenzene 
• 506-77-4 cyanogen chloride 
• 506-93-4 guanidine nitrate 
• 591-17-3 meta-bromotoluene 
• 625-95-6 3-Iodotoluene 
• 506-68-3 bromocyane 
• 620-51-9 N,N'-di(3-methylphenyl)thiourea 

Downstream Products

• 115209-84-2 7-methyl-N²,N⁴-di-m-tolyl-quinazoline-2,4-diyldiamine 
• 537-92-8 3-Methylacetanilide 
• 1550369-61-3 1-(m-tolyl)-2-(m-tolylamino)-1H-benzo[d]imidazol-6-ol 

Relevant articles and documents

Cleavage of C-N bonds in guanidine derivatives and its relevance to efficient C-N bonds formation

Efficient nonenzymatic decomposition of guanidine derivatives with high structural and functional diversity into anilide products is achieved in the presence of PdII/Cu(II) carboxylates/CO, relying on a dual C-N bonds cleavage strategy. In this decomposition process, the cooperative action of PdII species, Cu(II) carboxylates, and CO provides not only the N-acylating agents but also an initiator to trigger this C-N bonds cleavage sequence. The current results indicate that PdII/Cu(II) carboxylates/CO system provides a convenient and practical method for highly selective cleavage of unreactive C-N single bonds.

Synthesis of symmetrical and unsymmetrical N, N ′-diaryl guanidines via copper/N-methylglycine-catalyzed arylation of guanidine nitrate

CuI/N-methylglycine-catalyzed coupling reaction of guanidine nitrate with both aryl iodides and bromides takes place at 70-100 °C, affording symmetrical N,N′-diaryl guanidines with good to excellent yields. Unsymmetrical N,N′-diaryl guanidines can be assembled via monoarylation of guanidine nitrate with aryl iodides bearing a strong electron-withdrawing group and subsequent coupling with another aryl iodide.

SUBSTITUTED GUANIDINES HAVING HIGH BINDING TO THE SIGMA RECEPTOR AND THE USE THEREOF

The invention relates to a method for the treatment or prophylaxis of psychosis, depression, hypertension, or anxiety in an animal by administering an effective amount of an N,N'-disubstituted guanidine or 2-iminoimadazolidine having an affinity for the s