51134-82-8

Basic information

• Product Name: 2,3-Dihydro-2-methyl-6-nitro-1H-indole
• Synonyms: 2,3-Dihydro-2-methyl-6-nitro-1H-indole;6-Nitro-2-methylindoline;2-Methyl-6-nitroindoline
• CAS NO: 51134-82-8
• Molecular Formula: C9H10N2O2
• Molecular Weight: 178.19
• Mol File: 51134-82-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 306.9±31.0 °C(Predicted)
• Appearance: /
• Density: 1.217±0.06 g/cm3(Predicted)
• PKA: 3.45±0.40(Predicted)
• CAS DataBase Reference: 2,3-Dihydro-2-methyl-6-nitro-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dihydro-2-methyl-6-nitro-1H-indole(51134-82-8)
• EPA Substance Registry System: 2,3-Dihydro-2-methyl-6-nitro-1H-indole(51134-82-8)

Safety Data

• Hazardous Substances Data: 51134-82-8(Hazardous Substances Data)

Usage

Description

2,3-Dihydro-2-methyl-6-nitro-1H-indole, also known as CM-398, is a nitroindole derivative with a chemical formula C9H10N2O2 and a molecular weight of 174.19 g/mol. It is an organic compound used in the synthesis of various organic molecules and has potential applications in the pharmaceutical industry. Careful handling is advised due to potential health risks if not used properly.

Uses

Used in Pharmaceutical Industry:
2,3-Dihydro-2-methyl-6-nitro-1H-indole is used as a synthetic intermediate for the development of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the creation of new drugs with potential therapeutic benefits.
Used in Organic Synthesis:
In the field of organic synthesis, 2,3-Dihydro-2-methyl-6-nitro-1H-indole serves as a valuable building block for the assembly of complex organic molecules. Its versatility and reactivity make it a useful component in the synthesis of a wide range of organic compounds for various applications.

Upstream product

• 6872-06-6 2-methyl indoline 
• 7664-93-9 sulfuric acid 
• 95-20-5 2-methyl-1H-indole 

Downstream Products

• 103796-39-0 (±)-2-methylindolin-6-amine 
• 3484-23-9 2-methyl-6-nitro-1H-indole 

Relevant articles and documents

Kinetic Resolution of 2-Substituted Indolines by N-Sulfonylation using an Atropisomeric 4-DMAP-N-oxide Organocatalyst

The first catalytic kinetic resolution by N-sulfonylation is described. 2-Substituted indolines are resolved (s=2.6–19) using an atropisomeric 4-dimethylaminopyridine-N-oxide (4-DMAP-N-oxide) organocatalyst. Use of 2-isopropyl-4-nitrophenylsulfonyl chloride is critical to the stereodiscrimination and enables facile deprotection of the sulfonamide products with thioglycolic acid. A qualitative model that accounts for the stereodiscrimination is proposed.

New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone

A series of 2(1H)-pyrrolidino[3,2-g]quinolinones was prepared and tested for the ability to modulate the transcriptional activity of the human androgen receptor (hAR). The parent compound, 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone, displayed moderate interaction with hAR, but more substituted analogues, particularly 6,7-disubstituted compounds, were potent hAR agonists in vitro.