5115-98-0

Basic information

• Product Name: PIPERIDINE-3-CARBOXYLIC ACID METHYLAMIDE
• Synonyms: ART-CHEM-BB B025041;AKOS B025041;PIPERIDINE-3-CARBOXYLIC ACID METHYLAMIDE;AKOS 2B-001;N-METHYL-3-PIPERIDINECARBOXAMIDE;3-piperidinecarboxamide, N-methyl-;N-methyl-3-piperidinecarboxamide(SALTDATA: HCl)
• CAS NO: 5115-98-0
• Molecular Formula: C7H14N2O
• Molecular Weight: 142.2
• Mol File: 5115-98-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 69-70 °C
• Boiling Point: 318.5°C at 760 mmHg
• Flash Point: 149.6°C
• Appearance: /
• Density: 0.997g/cm³
• Vapor Pressure: 0.000361mmHg at 25°C
• Refractive Index: 1.462
• PKA: 16.05±0.20(Predicted)
• CAS DataBase Reference: PIPERIDINE-3-CARBOXYLIC ACID METHYLAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: PIPERIDINE-3-CARBOXYLIC ACID METHYLAMIDE(5115-98-0)
• EPA Substance Registry System: PIPERIDINE-3-CARBOXYLIC ACID METHYLAMIDE(5115-98-0)

Safety Data

• Hazardous Substances Data: 5115-98-0(Hazardous Substances Data)

Usage

General Description

PIPERIDINE-3-CARBOXYLIC ACID METHYLAMIDE is a chemical compound with the molecular formula C7H12N2O2. It is a derivative of piperidine, a heterocyclic compound with a six-membered ring containing one nitrogen atom. PIPERIDINE-3-CARBOXYLIC ACID METHYLAMIDE is commonly used in organic synthesis as a building block for various pharmaceuticals and agrochemicals. It has also been studied for its potential biological activities, including its role as an inhibitor of protein-protein interactions. Additionally, it is used as a reagent in the production of other complex organic compounds.

InChI:InChI=1/C7H14N2O/c1-8-7(10)6-3-2-4-9-5-6/h6,9H,2-5H2,1H3,(H,8,10)

Upstream product

• 114-33-0 N-Methylnicotinamide 
• 885698-91-9 3-methylcarbamoyl-piperidine-1-carboxylic acid tert-butyl ester 
• 71381-75-4 N-(tert-butyloxycarbonyl)nipecotic acid 
• 1161364-24-4 benzyl 3-(methylcarbamoyl)piperidine-1-carboxylate 

Relevant articles and documents

SUBSTITUTED FUSED TRICYCLIC COMPOUNDS, COMPOSITIONS AND MEDICINAL APPLICATIONS THEREOF

The present invention relates to substituted fused tricyclic compounds of formula (I) or (Ia), their tautomers, polymorphs, stereoisomers, prodrugs, solvates, co-crystals, pharmaceutically acceptable salts, pharmaceutical compositions containing them and methods of treating conditions and diseases that are mediated by JAK activity. The compounds of the present invention are useful in the treatment, prevention or suppression of diseases and disorders mediated by JAK activity. Such conditions include, but not limited to, arthritis, Alzheimer's disease, autoimmune thyroid disorders, cancer, diabetes, leukemia, T-cell prolymphocytic leukemia, lymphoma, myleoproliferation disorders, lupus, multiple myeloma, multiple sclerosis, osteoarthritis, sepsis, psoriatic arthritis, prostate cancer, T-cell autoimmune disease, inflammatory diseases, chronic and acute allograft transplant rejection, bone marrow transplant, stroke, asthma, chronic obstructive pulmonary disease, allergy, bronchitis, viral diseases, or Type I diabetes, complications from diabetes, rheumatoid arthritis, asthma, Crohn's disease, dry eye, uveitis, inflammatory bowel disease, organ transplant rejection, psoriasis and ulcerative colitis. The present disclosure also relates to process for the preparation of such compounds, and to pharmaceutical compositions containing them.

Di-oxanipecotic acids as more stable turn motifs than di-nipecotic acids

The folded structures of peptidomimetics containing dimers of oxanipecotic acid (Oxa) in loop segments were characterized and compared with those of the corresponding nipecotic acid (Nip)-based ones. According to structural studies using FT-IR and NMR spectroscopies, di-oxanipecotic acid adopted more stable turn conformations than di-nipecotic acid, and for tetramers, L,(S)-Oxa,(S)-Oxa,L and L,(S)-Oxa,(R)-Oxa,L formed hairpin-like structures but only L,(R)-Nip,(S)-Nip,L promoted the stable folded conformations.