511534-44-4

Basic information

• Product Name: (1R,2R)-N-Methylsulfonyl-1,2-diphenylethanediamine, 98+%
• Synonyms: (1R,2R)-N-Methylsulfonyl-1,2-diphenylethanediamine, 98+%;(1R,2R)-N-Methylsulfonyl-1,2-diphenylethanediamine;N-[(1R,2R)-2-Amino-1,2- diphenylethyl]methanesulfonamide,99%e.e.
• CAS NO: 511534-44-4
• Molecular Formula: C₁₅H₁₈N₂O₂S
• Molecular Weight: 290.38
• Mol File: 511534-44-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 117-119°C
• Appearance: /
• CAS DataBase Reference: (1R,2R)-N-Methylsulfonyl-1,2-diphenylethanediamine, 98+%(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2R)-N-Methylsulfonyl-1,2-diphenylethanediamine, 98+%(511534-44-4)
• EPA Substance Registry System: (1R,2R)-N-Methylsulfonyl-1,2-diphenylethanediamine, 98+%(511534-44-4)

Safety Data

• RIDADR: UN3259
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 511534-44-4(Hazardous Substances Data)

Usage

General Description

"(1R,2R)-N-Methylsulfonyl-1,2-diphenylethanediamine, 98+%" is a high purity chemical substance typically used in various research and industrial applications. (1R,2R)-N-Methylsulfonyl-1,2-diphenylethanediamine, 98+% belongs to the class of organic compounds known as sulfonamides, which are derivatives of sulfonic acid with an amine moiety. This particular is a chiral substance, as indicated by the "(1R,2R)" prefix, meaning that it has two stereocenters and exists in two distinct enantiomeric forms. The "98+%" denotes a high level of enantiomeric purity, meaning that it's made up of more than 98% of one particular enantiomer. The specific properties and uses of this chemical compound depend on the context in which it is applied.

Upstream product

• 35132-20-8 (R,R)-1,2-diphenylethylenediamine 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 1020665-72-8 N-((1R,2R)-2-(3-((1R,2R)-2-(dimethylamino)cyclohexyl)thioureido)-1,2-diphenylethyl)methanesulfonamide 
• 1333982-16-3 N-((1R,2R)-1,2-diphenyl-2-(2-(tetrahydro-2H-pyran-2-yloxy)ethylamino)ethyl)methanesulfonamide 
• 1360897-74-0 N-((1R,2R)-2-(2-((4,5-dimethylcyclohexa-1,4-dienyl)methoxy)ethylamino)-1,2-diphenylethyl)methanesulfonamide 
• 1394151-86-0 {Cp*Ir[(R,R)-Ms-DPEN](H₂O)}(SO₄) 

Relevant articles and documents

A four-hydrogenated 1, 8 - naphthyridine apperception composition preparation method and its prepared chiral products

The invention discloses a preparation method of a tetrahydro 1, 8-naphthyridine compound. The preparation method comprises the following steps: under the existence of a chiral catalyst, enabling a compound with the structure shown in the formula (1) (in the description) and hydrogen to be subjected to addition reaction, wherein the chiral catalyst is a coordination compound with the structure shown in the formula (2) (in the description). The invention further provides a chiral product of the tetrahydro 1, 8-naphthyridine compound, prepared through the preparation method. According to the invention, the proper compound with the structure shown in the formula (1) (in the description) is used as a substrate, and the proper coordination compound with the structure shown in the formula (2) (in the description) is used as the chiral catalyst to perform selective hydrogenation reduction on 1, 8-naphthyridine compound with the structure shown in the formula (1) by adopting hydrogen, so that the chiral product of the tetrahydro 1, 8-naphthyridine compound is prepared with low cost. The chiral product of the tetrahydro 1, 8-naphthyridine compound can be used as a biologically active compound and a structural building block of a chiral drug.

A four-hydrogenated 1, 5 - naphthyridine apperception composition preparation method and its prepared chiral products

The invention discloses a method for preparing a tetrahydro-1,5-naphthyridine compound. The method comprises the following steps: carrying out an addition reaction between a compound with the structure shown as a formula (1) and hydrogen in the presence of a chiral catalyst, wherein the chiral catalyst is a coordination complex with a structure shown as a formula (2). The invention also provides a chiral product of the tetrahydro-1,5-naphthyridine compound prepared by the method. The proper compound with the structure shown as the formula (1) is selected as a substrate, the proper coordination complex with the structure shown as the formula (2) is selected as the chiral catalyst, and selective hydrogenation reduction of the 1,5-naphthyridine compound with the structure shown as the formula (1) is realized by adopting hydrogen, so that the chiral product of the tetrahydro-1,5-naphthyridine compound is prepared at low cost. The chiral product of the tetrahydro-1,5-naphthyridine compound prepared by the invention can serve as a structure block of bioactive compounds and chiral drugs.

PH-independent transfer hydrogenation in water: Catalytic, enantioselective reduction of β-keto esters

A pH-independent asymmetric transfer hydrogenation of β-keto esters in water with formic acid/sodium formate is described. The reaction is conducted open to air and gives access to β-hydroxy esters in excellent yields and selectivities.