51164-31-9

Basic information

• Product Name: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (acetyl-methyl-amino)-methyl ester
• Synonyms: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (acetyl-methyl-amino)-methyl ester
• CAS NO: 51164-31-9
• Molecular Weight: 419.502
• Mol File: 51164-31-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (acetyl-methyl-amino)-methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (acetyl-methyl-amino)-methyl ester(51164-31-9)
• EPA Substance Registry System: (2S,5R,6R)-3,3-Dimethyl-7-oxo-6-phenylacetylamino-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid (acetyl-methyl-amino)-methyl ester(51164-31-9)

Safety Data

• Hazardous Substances Data: 51164-31-9(Hazardous Substances Data)

Upstream product

• 4270-65-9 N-methyl-N-chloromethylacetamide 
• 69-57-8 Penicillin G sodium 

Downstream Products

• 61-33-6 penicillin G 
• 7099-77-6 dimethylformamide-methanol 

Relevant articles and documents

A New Direct Synthesis of Tertiary N-Acyloxymethylamide Prodrugs of Carboxylic Acid Drugs

N-Alkyl-N-chloromethylamides 2, prepared from secondary amides, paraformaldehyde and chlorotrimethylsilane, react readily with carboxylate anions to generate the corresponding tertiary N-acyloxymethylamides 3 in good yield; the latter give rise to the parent carboxylic acids in aqueous media at pH 7.4 and 37 deg C with half-lives between ca. 1 min and 42 h.