51207-68-2

Basic information

• Product Name: (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol
• Synonyms: (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol;(2S)-N-Cbz-α,α-dimethyl-2-pyrrolidinemethanol,99%e.e.
• CAS NO: 51207-68-2
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.33214
• Mol File: 51207-68-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol(51207-68-2)
• EPA Substance Registry System: (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol(51207-68-2)

Safety Data

• Hazardous Substances Data: 51207-68-2(Hazardous Substances Data)

Usage

Description

(2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol, also known as Cbz-proline methyl ester, is a pyrrolidine derivative that serves as a protected form of proline, a non-essential amino acid crucial for protein synthesis and various metabolic functions. This chemical compound features a benzyloxycarbonyl (Cbz) protecting group, which is used to shield certain functional groups during chemical reactions, enabling selective manipulation of the molecule.

Uses

Used in Pharmaceutical Research:
(2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol is used as a building block for the synthesis of pharmaceuticals, leveraging its stability and compatibility with various reaction conditions to facilitate the development of new drugs.
Used in Organic Synthesis:
In the field of organic synthesis, (2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol is utilized as a key component in the creation of complex organic compounds, taking advantage of its protected structure to control reaction outcomes and improve synthetic efficiency.
Used in Peptide Synthesis:
(2S)-N-Cbz-α,α-diMethyl-2-PyrrolidineMethanol is employed as a protected amino acid in peptide synthesis, allowing for the stepwise assembly of peptide chains with controlled selectivity and minimized side reactions, ultimately leading to the formation of desired peptide sequences.

Upstream product

• 917-64-6 methyl magnesium iodide 
• 5211-23-4 N-carbobenzyloxy-L-proline methyl ester 
• 74-88-4 methyl iodide 
• 2577-48-2 methyl (2S)-pyrrolidine carboxylate 
• 147-85-3 L-proline 
• 75315-63-8 N-(benzyloxycarbonyl)succinimide 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 474317-28-7 (S)-2-(1-hydroxy-1-methylethyl)pyrrolidine hydrochloride 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 92053-25-3 (S)-(-)-2-(1-hydroxy-1-methylethyl)-pyrrolidine 
• 51207-70-6 (2S)-N-Benzyloxycarbony-2-(1'-methylethenyl)pyrrolidine 
• 111491-98-6 (2S)-2-Acetyl-N-(benzyloxycarbonyl)pyrrolidine 
• 313485-23-3 Ethyl (R)-4-[(2'S)-N-(benzyloxycarbonyl)pyrrolidin-2'-yl]-4-hydroxypent-2-ynoate 
• 313485-22-2 Ethyl (S)-4-[(2'S)-N-(benzyloxycarbonyl)pyrrolidin-2'-yl]-4-hydroxypent-2-ynoate 
• 77733-65-4 benzyl (S)-2-(2(R)-methyloxiranyl)-1-pyrrolidinecarboxylate 
• 77733-66-5 benzyl (S)-2-(2(S)-methyloxiranyl)-1-pyrrolidinecarboxylate 
• 67016-65-3 Pumiliotoxin B 
• 90246-45-0 (8S,8aS)-8-hydroxy-8-methyl-6(Z)-<4-(benzyloxy)-2(R)-methylbutylidene>octahydroindolizidine 
• 90246-46-1 (1S,7aS)-1-((Z)-(R)-6-Benzyloxy-4-methyl-2-trimethylsilanyl-hex-2-enyl)-1-methyl-tetrahydro-pyrrolo[1,2-c]oxazole 
• 90246-44-9 (1S ,7aS)-tetrahydro-1-methyl-1-<6-(benzyloxy)-4(R)-methyl-2-(trimethylsilyl)-2(Z)-hexenyl>-1H,3H-pyrrolo<1,2-c>oxazol-3-one 
• 90246-49-4 (8S,8aS)-8-hydroxy-8-methyl-6(Z)-<6-oxo-2(R),5-dimethyl-7(R)-(tert-butyldiphenylsiloxy)-4(E)-octenylidene>octahydroindolizidine 
• 118971-00-9 (S)-(-)-2-(1-methoxy-1-methylethyl)-pyrrolidine 
• 129149-57-1 (S)-N-formyl-2-(1-hydroxy-1-methylethyl)pyrrolidine 

Relevant articles and documents

2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF

[Problem] A compound which is useful as an active ingredient of a pharmaceutical composition for treating storage dysfunctions, voiding dysfunctions, and lower urinary tract diseases is provided. [Means for Solution] The present inventors have found that a thiazole derivative having pyrazine-2-carbonylamino substituted at the 2-position is an excellent muscarinic M3 receptor positive allosteric modulator, and is useful as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M3 receptor, thereby completing the present invention. The 2-acylaminothiazole derivative or a salt thereof of the present invention can be used as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M3 receptor, for example, voiding dysfunctions such as underactive bladder.

2-ACYLAMINOTHIAZOLE DERIVATIVE AND SALT THEREOF

[Problem] A compound which is useful as an active ingredient of a pharmaceutical composition for treating storage dysfunctions, voiding dysfunctions, and lower urinary tract diseases is provided. [Means for Solution] The present inventors have found that a thiazole derivative having pyrazine-2-carbonylamino substituted at the 2-position is an excellent muscarinic M 3 receptor positive allosteric modulator, and is useful as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M 3 receptor, thereby completing the present invention. The 2-acylaminothiazole derivative or a salt thereof of the present invention can be used as an agent for preventing and/or treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic M 3 receptor, for example, voiding dysfunctions such as underactive bladder.

A novel approach to the enantioselective formal synthesis of pumiliotoxin 251D

An efficient enantioselective synthesis of the indolizidine framework 9 of pumiliotoxin 251D in good yield by using a Lewis acid (cat.)-promoted diastereoselective addition of ethyl lithiopropiolate to ketone 7 derived from L-proline as a key step is reported. Hydrogenation of the addition product 8a gave the desired lactam 9. At the same time the 8-epimer of 9 was synthesized for the first time.