51211-55-3

Basic information

• Product Name: L-Proline, 1-L-prolyl-, phenylmethyl ester, monohydrochloride
• CAS NO: 51211-55-3
• Molecular Formula: C17H22N2O3.ClH
• Molecular Weight: 338.834
• Mol File: 51211-55-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: L-Proline, 1-L-prolyl-, phenylmethyl ester, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: L-Proline, 1-L-prolyl-, phenylmethyl ester, monohydrochloride(51211-55-3)
• EPA Substance Registry System: L-Proline, 1-L-prolyl-, phenylmethyl ester, monohydrochloride(51211-55-3)

Safety Data

• Hazardous Substances Data: 51211-55-3(Hazardous Substances Data)

Upstream product

• 37784-17-1 N-(tert-butoxycarbonyl)-D-proline 
• 16652-71-4 benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride 
• 141636-70-6 Boc-D-Pro-Pro-OBn 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 29776-70-3 N-(tert-butyloxycarbonyl)-prolyl-proline benzyl ester 

Downstream Products

• 103126-95-0 Phe-D-Pro-Pro-OBn hydrochloride 
• 88501-11-5 Boc-Phe-D-Pro-Pro-OBn 
• 140942-91-2 N-(4-methoxybenzylaminocarbonyl)-L-prolyl-L-proline benzyl ester 
• 133343-28-9 Boc-(L-Pro)3-L-Aze-Opcp 
• 103725-91-3 Boc-Val-Val-Val-Pro-Pro-Phe-Leu-Gln-Pro-OBzl 
• 103725-93-5 Boc-Val-Val-Val-Pro-Pro-Phe-Leu-OBzl 
• 103725-84-4 Boc-Val-Val-Val-Pro-Pro-OBzl 
• 103725-82-2 Boc-Val-Val-Pro-Pro-OBzl 
• 215393-56-9 (S)-1-[(S)-1-((S)-2-{[(S)-2-((S)-2-Dimethylamino-3-methyl-butyrylamino)-3-methyl-butyryl]-methyl-amino}-3-methyl-butyryl)-pyrrolidine-2-carbonyl]-pyrrolidine-2-carboxylic acid benzyl ester 
• 246506-80-9 1-{1-[2-(3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutyrylamino)-4-methyl-pentanoyl]pyrrolidine-2-carbonyl}-pyrrolidine-2-carboxylic acid benzyl ester 
• 270085-21-7 N-(tert-butyloxycarbonyl)-valyl-valyl-methylvalyl-prolyl-proline benzyl ester 
• 58872-04-1 Boc-Val-Pro-Pro-OBzl 
• 29776-73-6 Boc(L-Pro)4-Obn 
• 29776-72-5 Boc-Pro-Pro-Pro-OBzl 

Relevant articles and documents

Molecular capture and conformational change of diketopiperazines containing proline residues by epigallocatechin-3-O-gallate in water

The addition of an aqueous solution of diketopiperazine cyclo(Pro-Xxx) (Xxx: amino acid residue) to an aqueous solution of (?)-epigallocatechin-3-O-gallate (EGCg) led to precipitation of the complex of EGCg and cyclo(Pro-Xxx). The molecular capture abilities of cyclo(Pro-Xxx) using EGCg were evaluated by the ratio of the amount of cyclo(Pro-Xxx) included in the precipitates of the complex with EGCg to that of the total cyclo(Pro-Xxx) used. Stronger hydrophobicity of the side chain of the amino acid residue of cyclo(Pro-Xxx) led to a higher molecular capture ability. Furthermore, the molecular capture ability decreased when the side chain of the amino acid residue had a hydrophilic hydroxyl group. When diketopiperazine cyclo(Pro-Xxx), excluding cyclo(D-Pro-L-Ala), was taken into the hydrophobic space formed by the three aromatic A, B, and B′ rings of EGCg, and formed a complex, their conformation was maintained in the hydrophobic space. Based on nuclear Overhauser effect (NOE) measurement, the 3-position methyl group of cyclo(D-Pro-L-Ala) in D2O was axial, whereas that of cyclo(L-Pro-L-Ala) was equatorial. When cyclo(D-Pro-L-Ala) was taken into the hydrophobic space of EGCg and formed a 2:2 complex, its 3-position methyl group changed from the axial position to the equatorial position due to steric hindrance by EGCg.

Highly Potent and Selective Heptapeptide Antagonists of the Neurokinin NK-2 Receptor

Incorporation of D-Pro9 into substance P related peptides is known to enhance neurokinin NK-2 receptor agonist potency and selectivity with respect to other neurokinin receptors.We now report that replacement of D-Trp9 by D-Pro9