51236-93-2

Basic information

• Product Name: salicylaldehyde-N⁽⁴⁾-methylthiosemicarbazone
• Synonyms: salicylaldehyde-N⁽⁴⁾-methylthiosemicarbazone
• CAS NO: 51236-93-2
• Molecular Weight: 209.272
• Mol File: 51236-93-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: salicylaldehyde-N⁽⁴⁾-methylthiosemicarbazone(CAS DataBase Reference)
• NIST Chemistry Reference: salicylaldehyde-N⁽⁴⁾-methylthiosemicarbazone(51236-93-2)
• EPA Substance Registry System: salicylaldehyde-N⁽⁴⁾-methylthiosemicarbazone(51236-93-2)

Safety Data

• Hazardous Substances Data: 51236-93-2(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 6610-29-3 4-methylthiosemicarbazide 
• 6610-29-3 1-amino-3-methylisothiourea 

Downstream Products

• 1415313-63-1 [Ni2(κ3-O, N3, S-C9H9N3OS)2(μ-P, P-bis(diphenylphosphino)methane)] 
• 61872-09-1 C₉H₉N₃OS^(2-)*Cu⁽²⁺⁾ 
• 1173720-53-0 [Cu2I2(μ-S-salicylaldehyde N-methyl thiosemicarbazone)2(triphenylphosphine)2]*CH3CN 
• 1173720-59-6 [CuCl(η1-S-salicylaldehyde N-methyl thiosemicarbazone)(triphenylphosphine)2]*CH3CN 
• 866926-03-6 MoO₂(salicylaldehyde 4-methylthiosemicarbazone-2H) 

Relevant articles and documents

Modifying aroylhydrazone prochelators for hydrolytic stability and improved cytoprotection against oxidative stress

BSIH ((E)-N′-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzylidene)isonicotinohydrazide) is a prodrug version of the metal chelator SIH ((E)-N′-(2-hydroxybenzylidene)isonicotinohydrazide) in which a boronate group prevents metal chelation until reac

Four copper(II) compounds synthesized by anion regulation: Structure, anticancer function and anticancer mechanism

Copper (Cu) compounds are a promising candidate for next generation metal anticancer drugs. Therefore, we regulated anions to synthesize four mononuclear and binuclear Cu(II) compounds derived from thiosemicarbazone Schiff base ligands and characterized them. Four of these compounds showed very high cytotoxicity to cancer cell lines in vitro. These Cu(II) compounds strongly promoted the apoptosis of BEL-7404 cells and had a capacity to arrest the cell cycle at S phase of those cells. Furthermore, reactive oxygen species (ROS), mitochondrial membrane potential and Western blot analyses revealed that these Cu(II) compounds exert their cytotoxicity through an ROS-mediated intrinsic mitochondrial pathway accompanied by the regulation of Bcl-2 family proteins.

ROLES OF MODULATORS OF INTERSECTIN-CDC42 SIGNALING IN ALZHEIMER'S DISEASE

Methods of treating Alzheimer's disease and other neurodegenerative and/or neurocognitive and/or neurodevelopmental diseases are described. The methods comprise the administration of compounds that modulate an activity of cell division control protein 42 (Cdc42), such as the interaction between Cdc42 and intersectin (ITSN). Exemplary modulator compounds include thioureas, disulfonamides of fused aromatic systems (e.g., benzofuran), and acyl hydrazones, among others. Some of the modulator compounds act as activators of Cdc42, while others act as inhibitors. In some cases, the modulator compound has dual functionality and the ability of the modulator compound to act as an inhibitor or activator depends on whether or not Cdc42 is already activated in a particular disease stage or biological environment by an upstream activating signal of Cdc42.