51255-18-6

Basic information

• Product Name: Methyl-2-deoxy-beta-D-ribofuranoside
• Synonyms: METHYL-2-DEOXY-BETA-D-RIBOFURANOSIDE;BETA-D-ERYTHRO-PENTOFURANOSIDE;Methyl-2-deoxy-beta-D-ribofura;Methyl2-deoxy-b-D-ribofuranoside;B-D-ERYTHRO-PENTOFURANOSIDE
• CAS NO: 51255-18-6
• Molecular Formula: C₆H₁₂O₄
• Molecular Weight: 148.16
• Mol File: 51255-18-6.mol
• Article Data: 89

Chemical Properties

• Boiling Point: 294.5 °C at 760 mmHg
• Flash Point: 131.9 °C
• Appearance: /
• Density: 1.24 g/cm³
• Vapor Pressure: 0.000169mmHg at 25°C
• Refractive Index: 1.487
• PKA: 13.81±0.60(Predicted)
• CAS DataBase Reference: Methyl-2-deoxy-beta-D-ribofuranoside(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl-2-deoxy-beta-D-ribofuranoside(51255-18-6)
• EPA Substance Registry System: Methyl-2-deoxy-beta-D-ribofuranoside(51255-18-6)

Safety Data

• Hazardous Substances Data: 51255-18-6(Hazardous Substances Data)

Usage

General Description

Methyl-2-deoxy-beta-D-ribofuranoside, also known as 2-deoxyribose, is a synthetic derivative of the sugar ribose. It is a key component in the synthesis of nucleosides, which are essential building blocks of nucleic acids like DNA and RNA. This chemical is commonly used in the field of molecular biology and biochemistry for the synthesis of nucleoside analogs to study their effects on cellular processes. Additionally, it has potential applications in the development of antiviral and anticancer drugs. Methyl-2-deoxy-beta-D-ribofuranoside is a valuable tool for researchers studying nucleic acid biology and developing new therapeutic agents.

InChI:InChI=1/C6H12O4/c1-9-6-2-4(8)5(3-7)10-6/h4-8H,2-3H2,1H3/t4-,5+,6-/m0/s1

Upstream product

• 533-67-5 2-Deoxy-D-ribose 
• 67-56-1 methanol 
• 22900-10-3 2-deoxy-D-ribose 
• 91547-59-0 (2R,3S)-2-(hydroxymethyl)tetrahydrofuran-3-ol 
• 452-51-7 D-2-deoxyribose 
• 79364-36-6 (2R,3S)-hex-5-ene-1,2,3-triol 
• 131451-60-0 (1R,2R,4aS,5S,8aR)-2-(2-Hydroxy-ethyl)-5-methoxymethoxy-1-methyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester 
• 36792-88-8 2-deoxy-D-ribose 
• 77909-74-1 2,5-anhydro-3-deoxy-D-ribo-hexonic acid 
• 75-36-5 acetyl chloride 
• 22900-10-3 2-deoxy-β-D-erythro-pentopyranose 
• 137873-06-4 2,5,6-trideoxy-D-erythro-hexofuranose 
• 51785-71-8 methyl 2'-deoxy-3',5'-O-bis(p-nitrobenzoyl)-β-D-ribofuranoside 
• 113666-60-7 methyl 2-deoxy-3-O-benzyl-β-D-erythro-pentofuranoside 

Downstream Products

• 60110-69-2 methyl 2-deoxy-3,5-di-O-p-toluenesulfonyl-D-erythro-pentofuranoside 
• 17676-20-9 methyl 2-deoxy-β-D-erythro-pentopyranoside 
• 51785-70-7 methyl 3,5-dibenzoyloxy-2-deoxy-β-D-erythropentofuranoside 
• 80339-59-9 methyl 3,5-dibenzoyloxy-2-deoxy-α-D-erythropentofuranoside 
• 60251-58-3 methyl 2-deoxy-5-O-(p-toluenesulfonyl)-β-D-erythro-pentofuranoside 
• 151767-35-0 3,5-di-O-acetyl-2-deoxy-α/β-D-ribofuranoside 
• 132487-16-2 methyl 3,5-di-O-benzyl-2-deoxy-D-ribofuranoside 
• 6160-55-0 methyl 3,5-di-O-benzyl-2-deoxy-β-D-erythro-pentofuranoside 
• 6160-54-9 methyl 3,5-di-O-benzyl-2-deoxy-α-D-erythro-pentofuranoside 
• 108647-88-7 ((2R,3S)-3-(benzoyloxy)-5-methoxytetrahydrofuran-2-yl)methyl benzoate 
• 144071-99-8 1-methyl-5-O-benzoyl-2-deoxy-α-D-ribofuranoside 
• 144072-00-4 1-methyl-5-O-benzoyl-2-deoxy-β-D-ribofuranoside 
• 4330-34-1 methyl 3,5-di-O-toluoyl-2-deoxy-D-ribofuranose 
• 676598-19-9 methyl 2-deoxy-5-O-(4-methylbenzoyl)-D-erythro-pentofuranoside 

Relevant articles and documents

The Solution Conformational Preferences of the Sugar and Sugar Phosphate Constituents of RNA and DNA

The analysis of the proton NMR spectra of stereospecifically deuterated (S)-tetrahydrofuranmethanol, methyl β-D-ribofuranoside, methyl β-D-2-deoxyribofuranoside, and the 5-phosphates of the sugar acetals leads to several important and previously unrecogni

2-deoxy-D-ribose derivative

The invention belongs to the field of medicine synthesis, and provides a 2-deoxy-D-ribose derivative (III). When the derivative (III) is used for preparing decitabine, the stereoselectivity is good, and the yield is high. The invention provides a preparation method of the derivative. The preparation method comprises the following steps: step a, carrying out oxygen methylation on 1-position hydroxyl of 2-deoxy-D-ribose; and step b, protecting hydroxyl groups at positions 3 and 5, and further carrying out sulfonation on 1-position oxymethyl. The method is simple and convenient to operate, free of special equipment, good in product purity, high in yield and suitable for industrial production.

The development of β-selective glycosylation reactions with benzyl substituted 2-deoxy-1,4-dithio-D-erythro-pentofuranosides: enabling practical multi-gram syntheses of 4'-Thio-2'-deoxycytidine (T-dCyd) and 5-aza-4’-thio-2’-deoxycytidine (aza-T-dCyd) to s

The lack of effective methods to perform direct β-selective glycosylation reactions with 2-deoxy-1,4-dithio-D-erythro-pentofuranosides has long been a significant stumbling block for the multi-gram synthesis of 4’-thio-2’-deoxy nucleosides. In addition, p