512785-30-7Relevant articles and documents
Azetidinones as vasopressin V1a antagonists
Guillon, Christophe D.,Koppel, Gary A.,Brownstein, Michael J.,Chaney, Michael O.,Ferris, Craig F.,Lu, Shi-fang,Fabio, Karine M.,Miller, Marvin J.,Heindel, Ned D.,Hunden, David C.,Cooper, Robin D.G.,Kaldor, Stephen W.,Skelton, Jeffrey J.,Dressman, Bruce A.,Clay, Michael P.,Steinberg, Mitchell I.,Bruns, Robert F.,Simon, Neal G.
, p. 2054 - 2080 (2007/10/03)
The azetidinone LY307174 (1) was identified as a screening lead for the vasopressin V1a receptor (IC50 45 nM at the human V1a receptor) based on molecular similarity to ketoconazole (2), a known antagonist of the luteinizing hormone releasing h