51326-00-2

Basic information

• Product Name: 2-Cyclohexen-1-one,2-bromo-3-ethoxy-(9CI)
• Synonyms: 2-Cyclohexen-1-one,2-bromo-3-ethoxy-(9CI);2-Cyclohexen-1-one,2-bromo-3-ethoxy-
• CAS NO: 51326-00-2
• Molecular Formula: C₈H₁₁BrO₂
• Molecular Weight: 219.07574
• Product Categories: CYCLOHEXANONE
• Mol File: 51326-00-2.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Cyclohexen-1-one,2-bromo-3-ethoxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Cyclohexen-1-one,2-bromo-3-ethoxy-(9CI)(51326-00-2)
• EPA Substance Registry System: 2-Cyclohexen-1-one,2-bromo-3-ethoxy-(9CI)(51326-00-2)

Safety Data

• Hazardous Substances Data: 51326-00-2(Hazardous Substances Data)

Upstream product

• 5323-87-5 3-Ethoxycyclohex-2-en-1-one 

Downstream Products

• 51326-26-2 α-bromo-3-methylcyclohex-2-en-1-one 
• 60060-44-8 2-bromocyclohexane-1,3-dienone 
• 459174-24-4 3-ethoxy-2-(4-fluorophenyl)-cyclohexen-1-one 
• 73960-97-1 3-ethoxy-2-phenyl-2-cyclohexen-1-one 
• 890123-53-2 2-bromo-3-(4-methoxybutyl)cyclohex-2-en-1-one 
• 890123-54-3 (R)-2-bromo-3-(4-methoxybutyl)cyclohex-2-en-1-ol 
• 890123-56-5 (S)-2-[1-(4-methoxybutyl)cyclohex-2-en-1-yl]-N,N-dimethylacetamide 
• 890123-57-6 (S)-2-[1-(4-hydroxybutyl)cyclohex-2-en-1-yl]-N,N-dimethylacetamide 
• 890123-59-8 methyl (S)-4-[1-(2-methoxy-2-oxoethyl)cyclohex-2-en-1-yl]butanoate 
• 890123-55-4 (S)-2-[2-bromo-1-(4-methoxybutyl)cyclohex-2-en-1-yl]-N,N-dimethylacetamide 
• 459174-28-8 3-bromo-2-phenyl-2-cyclohexen-1-one 
• 459174-05-1 methyl 6-oxo-3,4,5,6-tetrahydro-[1,1'-biphenyl]-2-carboxylate 
• 459174-29-9 3-bromo-2-(4-fluorophenyl)-2-cyclohexen-1-one 

Relevant articles and documents

Copper-Catalyzed Enantioselective 1,2-Reduction of Cycloalkenones

We report an asymmetric 1,2-reduction of cyclic α,β-unsaturated ketones to access various enantiomerically enriched cyclic allylic alcohols under mild conditions, catalyzed by in situ generated copper hydride ligated with (R)-DTBM-C3*-TunePhos. α-Brominated cycloalkenones were reduced with excellent enantioselectivities of up to 98% ee, while substrates that were without α-substituents were reduced chemoselectively, with moderate enantioselectivities.

N-(1-(METHYLSULFONYL)PIPERIDIN-4-YL)-4,5-DI HYDRO-1H-IMIDAZO[4,5-H]QUINAZOLIN-8-AMINE DERIVATIVES AND RELATED COMPOUNDS AS CYCLIN-DEPENDENT KINASE 2 (CDK2) INHIBITORS FOR TREATING CANCER

The present application provid es tricyclic amine compounds of formula (I) as inhibitors of cyclin-dependent kinase 2 (CDK2) for treating cancer. Preferred compounds are N-(1-(methylsulfonyl)piperidin-4- yl)-4,5-dihydro-lH-imidazo[4,5-h]quinazolin-8-amine and the corresponding 6,8-dihydro-5H-pyrazolo[3,4-h]quinazolin-2-amine, 6,8- dihydropyrazolo[4',3':4,5]pyrano[3,2-d]pyrimidin-2-amine and 1,4- dihydroimidazo[4',5': 4,5]pyrano[3,2-d]pyrimidin-8-amine derivatives of formulae (IVa) to (IVd). The present description discloses the synthesis and characterisation of exemplary compounds as well as pharmacological data thereof (e.g. pages 128 to 166; examples 1 to 32, A and B1 to B10; table 1). Exemplary compound are e.g.: N-(1-(ethylsulfonyl)piperidin-4-yl)-l,2-dimethyl-4,5-dihydro-1H- imidazo[4,5-h]quinazolin-8-amine (example 1) 8-Methyl-N-(1-(methylsulfonyl)piperidin-4-yl)-6,8-dihydro-5H- pyrazolo[3,4-h]quinazolin-2-amine (example 9) 8-Methyl-N-(1-(methylsulfonyl)piperidin-4-yl)-6,8- dihydropyrazolo[4',3':4,5]pyrano[3,2-d]pyrimidin-2-amine (example 10) 1-cyclopropyl-N-(1-(methylsulfonyl)piperidin-4-yl)-l,4- dihydroimidazo[4',5':4,5]pyrano [3,2-d]pyrimidin-8-amine (example 26).

Efficient Synthesis of Anastrephin via the Allylic Substitution for Quaternary Carbon Construction

Lactone-moiety-attached 2-cyclohexylideneethyl picolinate was prepared through the OH-directed epoxidation (98% ds) of (R)-3-methylcyclohex-2-en-1-ol (99% ee), Horner-Wadsworth-Emmons olefination, conversion to the allylic moiety, and epoxide ring opening