51344-13-9

Basic information

• Product Name: 4-(2-N,N-Dimethylaminoethoxyl)-1-nitrobenzene
• Synonyms: 4-(2-N,N-Dimethylaminoethoxyl)-1-nitrobenzene;N,N-Dimethyl-2-(4-nitrophenoxy)ethanamine;N,N-dimethyl-2-(4-nitrophenoxy)ethylamine;N,N-Dimethyl-2-(4-nitrophenoxy)-1-ethanamine
• CAS NO: 51344-13-9
• Molecular Formula: C₁₀H₁₄N₂O₃
• Molecular Weight: 210.23
• Product Categories: Amines;blocks;NitroCompounds
• Mol File: 51344-13-9.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 326.6 °C at 760 mmHg
• Flash Point: 151.3 °C
• Appearance: /
• Density: 1.154 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-(2-N,N-Dimethylaminoethoxyl)-1-nitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-N,N-Dimethylaminoethoxyl)-1-nitrobenzene(51344-13-9)
• EPA Substance Registry System: 4-(2-N,N-Dimethylaminoethoxyl)-1-nitrobenzene(51344-13-9)

Safety Data

• Hazardous Substances Data: 51344-13-9(Hazardous Substances Data)

Usage

General Description

4-(2-N,N-Dimethylaminoethoxyl)-1-nitrobenzene is a chemical compound with the molecular formula C10H14N2O3. It is a nitroaromatic compound that contains a nitro group and a dimethylaminoethoxy group attached to a benzene ring. 4-(2-N,N-Dimethylaminoethoxyl)-1-nitrobenzene is commonly used as an intermediate in the production of dyes, pharmaceuticals, and other organic compounds. It is also known for its use in the synthesis of various chemicals and as a reagent in organic chemistry reactions. However, it is important to handle this compound with caution as it is toxic and may pose health risks if not handled properly.

Upstream product

• 28341-54-0 4-(4-nitrophenoxy)butanoic acid 
• 4584-46-7 (2-chloroethyl)dimethylamine hydrochloride 
• 107-99-3 2-(dimethylamino)ethyl chloride 
• 824-78-2 4-nitrophenol sodium salt 
• 100-02-7 4-nitro-phenol 
• 108-01-0 2-(N,N-dimethylamino)ethanol 
• 350-46-9 4-Fluoronitrobenzene 
• 3383-72-0 1-(2-chloroethoxy)-4-nitrobenzene 
• 506-59-2 N,N-dimethylammonium chloride 
• 124-40-3 dimethyl amine 
• 107-04-0 1-Bromo-2-chloroethane 
• 5407-04-5 3-(dimethylamino)propyl chloride hydrochloride 
• 16365-27-8 2-(4-nitrophenoxy)ethanol 
• 13288-06-7 1-(2-bromoethoxy)-4-nitrobenzene 

Downstream Products

• 62345-76-0 4-<2-(dimethylamino)ethoxy>aniline 
• 2603-70-5 C₃₀H₄₈N₄O₆⁽²⁺⁾*2Br^(1-) 
• 100839-68-7 N,N-dimethyl-2-(p-iodophenoxy)ethanamide hydrochloride 
• 93790-57-9 O-(4-iodophenyl)choline 
• 93790-54-6 [2-(4-iodophenoxy)ethyl]dimethylamine 
• 128457-34-1 N-(6,11-dihydrodibenzothiepin-11-yl)-4-(2-dimethylaminoethoxy)aniline 
• 128457-36-3 N-(2-methyl-6,11-dihydrodibenzothiepin-11-yl)-4-(2-dimethylaminoethoxy)aniline 
• 128457-35-2 N-(2-chloro-6,11-dihydrodibenzothiepin-11-yl)-4-(2-dimethylaminoethoxy)aniline 
• 2602-32-6 C₃₀H₅₂N₄O₂⁽²⁺⁾*2Br^(1-) 
• 1430234-69-7 C₂₇H₂₈N₆O₃ 

Relevant articles and documents

Mustard Carbonate Analogues as Sustainable Reagents for the Aminoalkylation of Phenols

N,N-dialkyl ethylamine moiety can be found in numerous scaffolds of macromolecules, catalysts, and especially pharmaceuticals. Common synthetic procedures for its incorporation in a substrate relies on the use of a nitrogen mustard gas or on multistep syntheses featuring chlorine hazardous/toxic chemistry. Reported herein is a one-pot synthetic approach for the easy introduction of aminoalkyl chain into different phenolic substrates through dialkyl carbonate (β-aminocarbonate) chemistry. This new direct alcohol substitution avoids the use of chlorine chemistry, and it is efficient on numerous pharmacophore scaffolds with good to quantitative yield. The cytotoxicity via MTT of the β-aminocarbonate, key intermediate of this synthetic approach, was also evaluated and compared with its alcohol precursor.

MACROCYCLIC COMPOUND SERVING AS WEE1 INHIBITOR AND APPLICATIONS THEREOF

Disclosed in the present invention are a macrocyclic compound serving as a Weel inhibitor, and applications thereof in the preparation of drugs for treating Weel-related diseases. The present invention specifically relates to a compound represented by for

8,9-DIHYDROIMIDAZOLE[1,2-A]PYRIMIDO[5,4-E]PYRIMIDINE-5(6H)-KETONE COMPOUND

Disclosed are 8,9-dihydroimidazo[1,2-a]pyrimido[5,4-e]pyrimidin-5(6H)-one compounds, specifically represented by the Formula I: or a pharmaceutically acceptable salt or prodrug thereof, wherein A and R1-R7 are defined herein. Compounds having Formula I are Wee1 kinase inhibitors. Therefore, compounds of the disclosure may be used to treat diseases caused by abnormal Wee1 activity.