51373-27-4Relevant articles and documents
Method for synthesizing 24-epibrassinolide
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Paragraph 0017; 0027; 0031; 0035; 0039; 0043, (2020/04/22)
The invention belongs to the technical field of organic synthesis. Based on a seven-step synthesis process, p-toluene sulfonyl chloride is used as an acylation reagent; a manganese dioxide/air catalytic system is used in a water and methanol system; and a calcium/HMPA/R1(CH2)nR2 reduction system is used. According to the synthesis method of the 24-epibrassinolide, ergosterol is used as a startingraw material, a seven-step synthesis process is adopted, the method comprises esterification, hydrolysis, oxidation, reduction, rearrangement, dihydroxylation and lactonization; methylbenzene is usedas a solvent in the esterification process, and ergosterol reacts with benzene sulfonyl chloride in the presence of an acid-binding agent; wherein a manganese dioxide/air system is adopted in the oxidation process, methanol is used as a solvent, and oxidation is performed in air; and a calcium/R1(CH2)nR2//HMPA/reduction system is adopted in the reduction process. According to the synthesis method,the total yield is increased by 20 points or above, the product quantitative content is 85% or above, the reaction condition is mild, the technological process is short, the operation is convenient,manganese dioxide can be recycled, low toxicity and low environmental pollution are achieved, and the synthesis method is suitable for industrial production of 24-epibrassinolide.
The shortest route from ergosterol to 24-epibrassinolide and its 22S,23S-isomer
Traven, V.FS.,Kuznetsova, N.A.,Levinson, E.E.,Podkhalyuzina, N.Ya.
, p. 96 - 98 (2007/10/02)
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