514-73-8 Usage
Chemical Properties
green crystalline powder
Originator
Delvex,Lilly,US,1958
Uses
Different sources of media describe the Uses of 514-73-8 differently. You can refer to the following data:
1. It is employed as a solvent soluble laser dye. DTDCi is used as fluorescent contrast agent in three-dimensional fluorescence lifetime tomography and as a dye for rapid genetic screening. It is a potential sensitive probe useful for fluorometric analysis of transferable membrane pores and effects of membrane potential on Na cotransports in eel intestinal brush-border membrane vesicles.
2. DTDCi is used as;Fluorescent contrast agent in three-dimensional fluorescence lifetime tomography.Dye for rapid genetic screening.
3. Sensitizer for photographic emulsions.
Manufacturing Process
3.05 g of 1-methylbenzthiazole ethiodide, 1.11 g of β-ethyl thio acrolein
diethyl acetal and 15 cc of pyridine were mixed and boiled gently under reflux
for 15 minutes. The reaction mixture was then poured into an aqueous
solution of potassium iodide. The dye was precipitated and was filtered off,
and washed with ethyl alcohol and ether. Recrystallization from methyl alcohol
solution yielded the dye as green needles. Melting point 248°C with
decomposition.
Brand name
Abminthic;Anguifugan;D.i.m.;Deselmine;Dilombrine;Dithiazine (dye);Dizan;Eastman 7663;Elmizin;Nekel;Omni-passin;Ossiurene;Telmicid;Telmide.
Therapeutic Function
Anthelmintic
World Health Organization (WHO)
Dithiazanine iodide, an anthelminthic, was introduced in 1959 for
the treatment of strongyloid worms and whipworms. Between 1961 and 1964 its
use was associated with eight fatal cases of severe acidosis and shock. Although
the drug is not significantly absorbed from the gut, in normal circumstances it was
assumed that these fatalities were due to atypically high uptake from inflamed
intestinal mucosa. Dithiazanine iodide has been superseded by safer and more
effective drugs; however, it may remain available in some countries.
General Description
Green, needle-like crystals. Used as a veterinary anthelmintic, as a sensitizer for photographic emulsions and as an insecticides. Not registered as a pesticide in the U.S.
Reactivity Profile
An amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Health Hazard
Highly toxic by mouth. (Non-Specific -- Pesticide, Solid, n.o.s.) Poisonous if swallowed, or if dust is inhaled.
Fire Hazard
When heated to decomposition, 3,3'-DIETHYLTHIADICARBOCYANINE IODIDE emits toxic fumes of iodine, sulfur oxides, and nitrogen oxides.
Safety Profile
Poison by ingestion,
intraperitoneal, and intravenous routes.
When heated to decomposition it emits very
toxic fumes of I-, SOx, and NOx. See also
IODIDES.
Check Digit Verification of cas no
The CAS Registry Mumber 514-73-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 4 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 514-73:
(5*5)+(4*1)+(3*4)+(2*7)+(1*3)=58
58 % 10 = 8
So 514-73-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H16O/c1-7(2)8-4-5-10(3)9(6-8)11-10/h8-9H,1,4-6H2,2-3H3/t8-,9?,10?/m0/s1
514-73-8Relevant articles and documents
REACTIONS OF POLYMETHINE DYES. I. SYNTHESIS OF THE PSEUDOBASES OF POLYMETHINE DYES AND THEIR TRANSFORMATIONS
Vompe, A. F.,Ivanova, L. V.,Meskhi, L. M.,Monich, N. V.,Raikhina, R. D.
, p. 529 - 537 (2007/10/02)
Nonsalt-like benzene-soluble pseudobases are formed in the reaction of polymethine dyes with sodium alcoholates.The presence of ionized and un-ionized forms of the pseudobases was established by electronic absorption spectra in aprotic solvents.Solutions of these compounds in alcohols only contain the ionized forms; the unionized form predominates in benzene solutions.The action of various acids on the pseudobases leads to the production of polymethine dyes with the respective anions.
