514182-79-7

Basic information

• Product Name: 1-phenyl-1H-pyrrolo[3,2-b]pyridine
• Synonyms: 1-phenyl-1H-pyrrolo[3,2-b]pyridine
• CAS NO: 514182-79-7
• Molecular Weight: 194.236
• Mol File: 514182-79-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 1-phenyl-1H-pyrrolo[3,2-b]pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-1H-pyrrolo[3,2-b]pyridine(514182-79-7)
• EPA Substance Registry System: 1-phenyl-1H-pyrrolo[3,2-b]pyridine(514182-79-7)

Safety Data

• Hazardous Substances Data: 514182-79-7(Hazardous Substances Data)

Usage

Chemical Class

Pyrrolopyridine derivatives

Molecular Structure

1-phenyl-1H-pyrrolo[3,2-b]pyridine

Therapeutic Potential

Neuroprotection

Animal Study Results

Promotes neuron survival, protects against neurodegeneration

Potential Treatment for

Alzheimer's disease, Parkinson's disease, and traumatic brain injury

Ongoing Research

Exploring full range of pharmacological properties and potential as a novel neuroprotective agent.

Upstream product

• 272-49-1 1H-pyrrolo[3,2-b]pyridine 
• 591-50-4 iodobenzene 

Downstream Products

• 1175143-09-5 C₂₄H₂₀ClFN₄O₂ 
• 1175012-92-6 C₂₅H₂₃FN₄O₂ 
• 1175014-73-9 4-[2-(3-fluoro-2-methyl-benzyl)-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1175012-94-8 C₂₅H₂₃FN₄O₂ 
• 1175014-70-6 4-[1-phenyl-2-(2-methyl-phenoxy)-1H-pyrrolo[3,2-b]pyridine-3-carbonyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 1175014-69-3 4-(2-chloro-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carbonyl)-piperazine-1-carboxylic acid tert-butyl ester 
• 1175014-68-2 2-chloro-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carboxylic acid 
• 1175014-67-1 2-chloro-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carbaldehyde 
• 1175012-96-0 C₂₅H₂₃FN₄O₂ 
• 1175143-07-3 C₂₄H₂₀F₂N₄O₂ 
• 1175143-08-4 C₂₄H₂₀F₂N₄O₂ 
• 1175143-06-2 C₂₄H₂₁FN₄O₂ 
• 1175143-10-8 C₂₆H₂₆N₄O₂ 
• 1175016-02-0 4-(2-chloro-1-phenyl-1H-pyrrolo[3,2-b]pyridine-3-carbonyl)-2-methoxycarbonylmethyl-piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

Optimization of diarylpentadienones as chemotherapeutics for prostate cancer

Our earlier studies indicate that (1E,4E)-1,5-bis(1-alkyl-1H-imidazol-2-yl)penta-1,4-diene-3-ones and (1E,4E)-1,5-bis(1-alkyl-1H-benzo[d]imidazol-2-yl)penta-1,4-diene-3-ones exhibit up to 121-fold greater antiproliferative potency than curcumin in human p

Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors

The control of hypertension and associated cardiovascular risk factors is possible by selective inhibition of the aspartyl protease renin due to its unique position in the renin-angiotensin system. Starting from a previously disclosed series of potent and nonchiral indole-3-carboxamides, we further explored this motif by structure-based drug design guided by X-ray crystallography in combination with efficient parallel synthesis. This resulted in the discovery of 4- or 6-azaindole derivatives with remarkable potency for renin inhibition. The best compound from these series showed an IC50 value of 1.3 nM.