51431-59-5

Basic information

• Product Name: 2-(p-tolyl)but-3-en-2-ol
• Synonyms: 2-(p-tolyl)but-3-en-2-ol
• CAS NO: 51431-59-5
• Molecular Weight: 162.232
• Mol File: 51431-59-5.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-(p-tolyl)but-3-en-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(p-tolyl)but-3-en-2-ol(51431-59-5)
• EPA Substance Registry System: 2-(p-tolyl)but-3-en-2-ol(51431-59-5)

Safety Data

• Hazardous Substances Data: 51431-59-5(Hazardous Substances Data)

Upstream product

• 3536-96-7 vinylmagnesium chloride 
• 122-00-9 para-methylacetophenone 
• 1826-67-1 vinyl magnesium bromide 

Downstream Products

• 16939-05-2 3-(4-tolyl)thiophene 
• 259148-89-5 2-bromo-3-(p-tolyl)thiophene 
• 130633-06-6 (E)-3-(4-methylphenyl)-but-2-en-1-ol 
• 1047082-71-2 (E)-1’-methyl-4’-(4-bromobut-2-en-2-yl)benzene 
• 75316-62-0 C₁₃H₁₈ 
• 313990-14-6 1-methyl-4-(3-methylhexa-1,5-dien-3-yl)benzene 
• 66334-32-5 (R)-(-)-2-methyl-2-(4-methylphenyl)-4-oxopentanal 
• 123930-76-7 (S)-(-)-4-methyl-4-(4-methylphenyl)cyclopent-2-enone 
• 1311260-43-1 (S)-1-(3,5-dimethylhexa-1,5-dien-3-yl)-4-methylbenzene 
• 38829-06-0 1-(buta-1,3-dien-2-yl)-4-methylbenzene 
• 1311260-18-0 (S)-1-methyl-4-(3-methylhexa-1,5-dien-3-yl)benzene 
• 1311260-04-4 tert-butyl (2-(p-tolyl)but-3-en-2-yl) carbonate 
• 92152-01-7 biphenyl-3,4′-dicarboxylic acid 
• 7383-90-6 3,4'-dimethylbiphenyl 

Relevant articles and documents

Practical synthesis of aromatic bisabolanes: Synthesis of 1,3,5-bisabolatrien-7-ol, peniciaculin A and B, and hydroxysydonic acid

The enantioselective synthesis of aromatic bisabolanes, such as 1,3,5-bisabolatrien-7-ol, peniciaculin A and B, and hydroxysydonic acid, has been described. Our methodology for the total synthesis of aromatic bisabolanes involves the stereoselective const

Regio- and Enantioselective Preparation of Chiral Allylic Sulfones Featuring Elusive Quaternary Stereocenters

We describe here the first general asymmetric synthesis of sterically encumbered α,α-disubstituted allylic sulfones via Pd-catalyzed allylic substitution. The design and application of a new and highly efficient phosphoramidite ligand (L10) proved to be crucial, and a wide variety of challenging allylic sulfones featuring quaternary stereocenters could be obtained in good yields and with good to excellent levels of regio- and enantioselectivities under attractive process conditions. The developed methodology employs easily accessible chemical feedstock including racemic allylic precursors and sodium sulfinates. The utility of the method is further demonstrated by the synthesis of the sesquiterpene (?)-Agelasidine A.

Improvements and Applications of the Transition Metal-Free Asymmetric Allylic Alkylation using Grignard Reagents and Magnesium Alanates

Two new N-heterocyclic carbene (NHC) ligands have been synthesized and employed in the transition metal-free asymmetric allylic alkylation (AAA) mediated by Grignard reagents and magnesium alanates. The employment of these ligands showed high yields and improved regio- and enantioselectivity in the formation of tertiary and quaternary stereocenters. Moreover, the low catalyst loading (up to 0.3 mol%) and high scalability (up to 10 mmol) of this improved methodology provide a convenient access to biologically active compounds and synthetically valuable intermediates.