51432-60-1

Basic information

• Product Name: 1,3-Dioxolane-4-methanol, 2,2-dimethyl-, benzoate, (4R)-
• CAS NO: 51432-60-1
• Molecular Formula: C13H16O4
• Molecular Weight: 236.268
• Mol File: 51432-60-1.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1,3-Dioxolane-4-methanol, 2,2-dimethyl-, benzoate, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxolane-4-methanol, 2,2-dimethyl-, benzoate, (4R)-(51432-60-1)
• EPA Substance Registry System: 1,3-Dioxolane-4-methanol, 2,2-dimethyl-, benzoate, (4R)-(51432-60-1)

Safety Data

• Hazardous Substances Data: 51432-60-1(Hazardous Substances Data)

Upstream product

• 22323-82-6 (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol 
• 93-97-0 benzoic acid anhydride 
• 1707-77-3 1,2:5,6-di-O-isopropylidene-D-mannitol 
• 98760-27-1 4-benzoyloxymethyl-2,2-dimethyl-[1,3]dioxolane 
• 98-88-4 benzoyl chloride 
• 100-79-8 (R,S)-2,2-dimethyl-1,3-dioxolane-4-methanol 
• 532-32-1 sodium benzoate 
• 57044-24-3 (R)-4-chloromethyl-2,2-dimethyl-1,3-dioxolane 

Downstream Products

• 22323-82-6 (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol 
• 118166-41-9 Benzoic acid (S)-2-hydroxy-3-phenylsulfanyl-propyl ester 
• 51432-61-2 (R)-1-benzoyloxy-2,3-propanediol 

Relevant articles and documents

Macrocyclic MCL-1 inhibitors and methods of use

The present disclosure provides for compounds of Formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents for the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of Formula (I).

Asymmetric synthesis of (4S,5S)-2-oxo-4-phenyloxazolidine-5-carboxylic acid using a 1,2-addition of PhMgBr to an N-sulfinimine derived from (R)-glyceraldehyde acetonide and (S)-t-BSA

We report an asymmetric synthesis of (4S,5S)-2-oxo-4-phenyloxazolidine-5- carboxylic acid via stereoselective addition of phenylmagnesium bromide (PhMgBr) to an N-sulfinimine derived from (R)-glyceraldehyde acetonide. (S)- and (R)-Glyceraldehyde acetonides, important chiral synthons in synthetic organic chemistry, are prepared from the corresponding epichlorohydrin using an identical synthetic methodology.

Enhanced enantioselectivity of Bacillus coagulans in the hydrolysis of 1,2-O-isopropylidene glycerol esters by thermal knock-out of undesired enzymes

The enantioselective hydrolysis of different (RS)-1,2-O-isopropylidene glycerol esters has been achieved with whole cells of Bacillus coagulans NCIMB 9365 furnishing the (S)-alcohol as the major enantiomer. The reaction is catalysed by a thermostable cell-bound carboxylesterase and improvement of the enantioselectivity has been achieved by heat treatment of the whole cells, which causes the knock-outs a non-enantioselective competing enzyme. Thermally-treated cells hydrolysed (RS)-1,2-O-isopropylidene glycerol esters with high enantioselectivity, the highest enantiomeric ratio (80-100) being observed for the benzoate. The biocatalyst displayed good stability and could be re-used after filtration for 12 cycles before showing significant loss of activity; repeated biotransformation batches allowed the recovery of 9.55 g/L of enantiomerically pure (S)-isopropylideneglycerol benzoate starting from 24.0 g/L of the racemic mixture.