51445-63-7 Usage
Description
2-Thienylglyoxal is a heterocyclic aromatic compound with the chemical formula C6H4O2S, featuring a thiophene ring attached to a glyoxal structure. It is known for its potential applications in the synthesis of pharmaceuticals and organic compounds, as well as its use as a fluorescent probe for detecting metal ions due to its high affinity for metal chelation. Furthermore, 2-Thienylglyoxal has been studied for its potential anti-inflammatory and antioxidant properties, making it a promising candidate in medicinal chemistry.
Uses
Used in Pharmaceutical Synthesis:
2-Thienylglyoxal is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds, contributing to the development of new drugs and therapeutic agents.
Used as a Fluorescent Probe in Analytical Chemistry:
2-Thienylglyoxal is used as a fluorescent probe for detecting different metal ions, owing to its high affinity for metal chelation. This property makes it a valuable tool in analytical chemistry for the detection and quantification of metal ions in various samples.
Used in Medicinal Chemistry for Anti-Inflammatory and Antioxidant Properties:
2-Thienylglyoxal is studied for its potential anti-inflammatory and antioxidant properties, making it a subject of interest in the field of medicinal chemistry. Its potential applications in this area could lead to the development of new treatments for inflammatory and oxidative stress-related conditions.
Used in Organic Chemistry for Synthesis of Hetrocyclic Compounds:
2-Thienylglyoxal is utilized in organic chemistry for the synthesis of heterocyclic compounds, which are important building blocks in the creation of various organic molecules and have applications in various industries, including pharmaceuticals, agrochemicals, and materials science.
Check Digit Verification of cas no
The CAS Registry Mumber 51445-63-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,4,4 and 5 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 51445-63:
(7*5)+(6*1)+(5*4)+(4*4)+(3*5)+(2*6)+(1*3)=107
107 % 10 = 7
So 51445-63-7 is a valid CAS Registry Number.
InChI:InChI=1/C6H4O2S/c7-4-5(8)6-2-1-3-9-6/h1-4H
51445-63-7Relevant articles and documents
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Kipnis,Ornfelt
, p. 2734 (1946)
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A novel class for carbonic anhydrases inhibitors and evaluation of their non-zinc binding
Kuzu, Burak,Tan, Meltem,Gül?in, ?lhami,Menges, Nurettin
, (2021/06/09)
In this study, 23 different imidazole derivatives were synthesized, and the inhibitory properties of these derivatives against carbonic anhydrase I and II isoenzymes were investigated for the first time. The inhibition concentrations of the imidazole derivatives were found to be in the range of 2.89–115.5 nM. Docking studies examined the binding properties of the imidazole derivatives, and the structure–activity relationship is discussed. Theoretical calculations showed that the binding mode of the imidazole ring was non-zinc binding.
Catalytic Asymmetric Darzens-Type Epoxidation of Diazoesters: Highly Enantioselective Synthesis of Trisubstituted Epoxides
Nam, Dong Guk,Shim, Su Yong,Jeong, Hye-Min,Ryu, Do Hyun
supporting information, p. 22236 - 22240 (2021/09/13)
Highly enantioselective Darzens-type epoxidation of diazoesters with glyoxal derivatives was accomplished using a chiral boron–Lewis acid catalyst, which facilitated asymmetric synthesis of trisubstituted α,β-epoxy esters. In the presence of a chiral oxazaborolidinium ion catalyst, the reaction proceeded in high yield (up to 99 %) with excellent enantio- and diastereoselectivity (up to >99 % ee and >20:1 dr, respectively). The synthetic potential of this method was illustrated by conversion of the products to various compounds such as epoxy γ-butyrolactone, tertiary β-hydroxy ketone and epoxy diester.
