514797-96-7

Basic information

• Product Name: 2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI)
• Synonyms: 2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI);5-chloro-3-fluoro-2-hdyroxypyridine;5-chloro-3-fluoro-2(1H)-Pyridinone;5-chloro-3-fluoropyridin-2(1H)-one
• CAS NO: 514797-96-7
• Molecular Formula: C₅H₃ClFNO
• Molecular Weight: 147.536
• Product Categories: PYRIDINE
• Mol File: 514797-96-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 71℃
• Boiling Point: 219℃
• Flash Point: 86℃
• Appearance: /
• Density: 1.46
• Vapor Pressure: 0.00864mmHg at 25°C
• Refractive Index: 1.552
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 8.90±0.10(Predicted)
• CAS DataBase Reference: 2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI)(514797-96-7)
• EPA Substance Registry System: 2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI)(514797-96-7)

Safety Data

• Hazardous Substances Data: 514797-96-7(Hazardous Substances Data)

Usage

General Description

"2(1H)-Pyridinone, 5-chloro-3-fluoro-(9CI)" is a specific type of chemical compound, which belongs to the class of organic chemicals called heterocyclic compounds. These compounds contain a cyclic structure with atoms of at least two different elements as members of its rings. The exact properties and uses of this specific chemical are largely dependent on its exact structure and the type of reactions it undergoes in certain conditions. The 2(1H)-Pyridinone portion of the name suggests the presence of pyridinone, a type of lactam, while the ‘5-chloro-3-fluoro’ indicates that the substance has been chemically modified with chlorine and fluorine groups, which could influence its reactivity and functionality. The coding '(9CI)' is a registry number that uniquely identifies this specific structure in chemical databases. The potential use or applications of this chemical compound may vary from pharmaceutical research, chemical engineering to materials science, which is subject to advanced research and analysis. The safety, environmental impact, and potential risks associated with this chemical also need to be assessed following standard chemical safety protocols.

InChI:InChI=1/C5H3ClFNO/c6-3-1-4(7)5(9)8-2-3/h1-2H,(H,8,9)

Upstream product

• 89402-43-7 5-chloro-2,3-difluoropyridine 

Downstream Products

• 103999-77-5 2,5-dichloro-3-fluoropyridine 
• 514797-99-0 3-chloro-5-fluoro-pyridine 
• 514798-07-3 3-chloro-5-fluoro-4-iodo-pyridine 
• 514797-98-9 5-chloro-3-fluoro-2-iodopyridine 
• 514798-11-9 3-chloro-5-fluoro-2-iodopyridine 
• 514798-03-9 3-chloro-5-fluoro-4-pyridinecarboxylic acid 
• 207994-08-9 5-chloro-3-fluoro-2-pyridinecarboxylic acid 
• 514798-04-0 2,5-dichloro-3-fluoro-4-iodopyridine 
• 514798-20-0 methyl 3-chloro-5-fluoro-6-iodo-2-pyridinecarboxylate 
• 514798-17-5 6-bromo-3-chloro-5-fluoro-2-pyridinecarboxylic acid 
• 514798-01-7 2-bromo-5-chloro-3-fluoro-4-pyridinecarboxylic acid 
• 514797-97-8 2-bromo-5-chloro-3-fluoro-pyridine 
• 1200498-38-9 C₆H₂ClFNO₂^(1-)*Li⁽¹⁺⁾ 
• 1200498-40-3 methyl 5-chloro-3-fluoropicolinate 

Relevant articles and documents

SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING ?-SECRETASE-INHIBITING ACTIVITY

The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid β protein, for example,. a compound represented by the formula (I): wherein ruing A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group, R1 is optionally substituted lower alkyl or the like, R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or the like, R3a and R3c are each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl or the like, or a pharmaceutically acceptable salt thereof, or a solvate thereof.

Creating structural manifolds from a common precursor: Basicity gradient-driven isomerization of halopyridines

5-Chloro-2,3-difluoropyridine, an intermediate in the manufacturing process of an industrial pesticide, can be hydrolyzed to 5-chloro-3-fluoro-2H-pyridinone and the latter converted into 2,5-dichloro-3-fluoropyridine (1a), 2-bromo-5-chloro-3-fluoropyridine (1b), 5-chloro-3-fluoro-2-iodopyridine (1c) and 3-chloro-5-fluoropyridine (1d). Consecutive treatment of these four substrates with lithium diisopropylamide and carbon dioxide or lithium diisopropylamide and iodine affords the corresponding 4-pyridinecarboxylic acids 2 and 4-iodopyridines 3, respectively. Amide-promoted deprotonation of such 4-iodopyridines 3 triggers an isomerization in which lithium and iodine change places. The resulting species can be trapped with carbon dioxide to give the acids 5a-c or neutralized to give the halopyridines 4a-c. The iodopyridines 4a and 4b can be converted into the acids 6a and 6b, the latter product leading also to the congeners 6c and 6d. The diiodopyridine 4c provides an entry to the halopyridine 4d, which at the same time may act as the precursor to the acid 5d, the acid 7 or the bisacid 8. Finally, the acid 9 is accessible from either one of the 5-chloro-3-fluoro-2-halopyridines 1b and 1c. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002).