51505-76-1

Basic information

• Product Name: 1H-IMIDAZOL-1-YLMETHANOL
• Synonyms: 1H-IMidazole-1-Methanol;1-Hydroxymethylimidazole;N-Hydroxymethylimidazole;1H-Imidazol-1-methanol;1H-IMIDAZOL-1-YLMETHANOL;imidazol-1-ylmethanol
• CAS NO: 51505-76-1
• Molecular Formula: C₄H₆N₂O
• Molecular Weight: 98.1032
• Product Categories: Imidazol&Benzimidazole
• Mol File: 51505-76-1.mol
• Article Data: 6

Chemical Properties

• Melting Point: 134℃
• Boiling Point: 307.7 °C at 760 mmHg
• Flash Point: 139.9 °C
• Appearance: /
• Density: 1.21±0.1 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.00031mmHg at 25°C
• Refractive Index: 1.564
• PKA: 11.72±0.10(Predicted)
• CAS DataBase Reference: 1H-IMIDAZOL-1-YLMETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-IMIDAZOL-1-YLMETHANOL(51505-76-1)
• EPA Substance Registry System: 1H-IMIDAZOL-1-YLMETHANOL(51505-76-1)

Safety Data

• Hazardous Substances Data: 51505-76-1(Hazardous Substances Data)

Usage

General Description

1H-Imidazol-1-ylmethanol, also known as imidazole-1-ylmethanol, is a chemical compound with the molecular formula C4H6N2O. It is a derivative of imidazole and is commonly used in organic synthesis as a building block for various pharmaceuticals and other compounds. 1H-Imidazol-1-ylmethanol has a wide range of applications, including as a reagent in the production of antifungal drugs, anticancer agents, and anti-inflammatory drugs. It is also used as a chelating agent in coordination chemistry and as a stabilizer in the preparation of polymers. Additionally, it has been studied for its potential as an antiviral and antitumor agent.

InChI:InChI=1/C4H6N2O/c7-4-6-2-1-5-3-6/h1-3,7H,4H2

Upstream product

• 288-32-4 1H-imidazole 
• 50-00-0 formaldehyd 

Downstream Products

• 1256485-18-3 (1H-imidazol-1-yl)methyl 4-(4-methoxyphenylamino)-6-(methylcarbamoyl)-quinoline-3-carboxylate 
• 1256485-40-1 4-(4-fluorophenyl-amino)-6-methylcarbamoylquinoline-3-carboxylic acid imidazol-1-yl-methyl ester 

Relevant articles and documents

-

-

Facile synthesis of a family of H8BINOL-amine compounds and catalytic asymmetric arylzinc addition to aldehydes

A family of optically active H8BINOL-AM compounds containing 3,3′-bis-tertiary amine substituents are synthesized by using a one-step reaction of H8BINOL with amino methanols that were in situ generated from various cyclic or acyclic secondary amines and paraformaldehyde. The H 8BINOL-AM compounds are used to catalyze the reaction of functional arylzincs, in situ prepared from the reaction of aryliodides with ZnEt 2, with aldehydes to produce chiral diaryl carbinols and a few arylalkyl carbinols. Through this study, highly enantioselective catalysts were identified. It was found that the H8BINOL-AM compounds with sterically less congested cyclic or acyclic amino methyl substituents were more enantioselective than those with more bulky substituents. The pyrrolidinyl derivative (S)-12 in most cases showed greater enantioselectivity than other H8BINOL-AM compounds, especially for the challenging ortho-substituted aromatic aldehydes. A H8BINOL-AM with 3,3′-bis-sec-amine substituents, prepared by a multistep method, was also used to catalyze the arylzinc addition to aldehydes, but it showed enantioselectivity lower than that of the compounds with tertiary amine groups. It was found for the first time that an aryl bromide, 2-bromothiophene, could be used to prepare an arylzinc reagent by reaction with ZnEt2. The addition of this heteroarylzinc reagent to an aldehyde in the presence of (S)-12 proceeded with good enantioselectivity.

MUSCARINIC RECEPTOR ANTAGONISTS

This present invention generally relates to muscarinic receptor antagonists, which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. The inve