515114-52-0

Basic information

• Product Name: (±)-3-(1-(dimethylamino)-2-methylpentan-3-yl)phenol
• Synonyms: (±)-3-(1-(dimethylamino)-2-methylpentan-3-yl)phenol
• CAS NO: 515114-52-0
• Molecular Weight: 221.343
• Mol File: 515114-52-0.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: (±)-3-(1-(dimethylamino)-2-methylpentan-3-yl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: (±)-3-(1-(dimethylamino)-2-methylpentan-3-yl)phenol(515114-52-0)
• EPA Substance Registry System: (±)-3-(1-(dimethylamino)-2-methylpentan-3-yl)phenol(515114-52-0)

Safety Data

• Hazardous Substances Data: 515114-52-0(Hazardous Substances Data)

Usage

Description

(±)-3-(1-(dimethylamino)-2-methylpentan-3-yl)phenol, also known as DMPP, is a synthetic chemical compound with a molecular formula of C14H23NO. It is a potent activator of the transient receptor potential cation channel, subfamily A, member 1 (TRPA1) and a transient receptor potential cation channel, subfamily V, member 1 (TRPV1). These ion channels are involved in the perception of pain, temperature, and inflammation.
Used in Pharmaceutical Industry:
DMPP is used as a medicinal compound for modulating TRPA1 and TRPV1 ion channels, which play a role in the perception of pain, temperature, and inflammation. Its activation of these channels has potential therapeutic applications in addressing pain and sensory disorders.
Used in Neurotransmitter Release Control:
DMPP is used as a research tool for studying the potential role of TRPA1 and TRPV1 channels in controlling the release of neurotransmitters. Understanding this mechanism could lead to the development of new treatments for neurological disorders.

Upstream product

• 1369205-81-1 toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-1-hydroxy-2-methylpropyl)phenyl ester 
• 1369205-84-4 toluene-4-sulfonic acid 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenyl ester 
• 1369205-80-0 toluene-4-sulfonic acid 3-propionylphenyl ester 
• 50-00-0 formaldehyd 
• 1369205-83-3 toluene-4-sulfonic acid 3-[1-(2-dimethylamino-1-methylethyl)propenyl]phenyl ester 
• 1369205-94-6 toluene-4-sulfonic acid 3-(3-dimethylamino-2-methylpropionyl)phenyl ester 
• 1343471-61-3 rac-3-(dimethylamino)-1-(3-hydroxyphenyl)-2-methylpropan-1-one 
• 13103-80-5 1-(3-hydroxyphenyl)propan-1-one 
• 1313429-14-9 2-cyano-3-(3-methoxy-phenyl)-pentanoic acid ethyl ester 
• 1313374-17-2 N,N-dimethyl-2-methyl-3-(3-methoxyphenyl)valeramide 
• 1313429-27-4 3-(3-methoxy-phenyl)-2-methyl-pentanoic acid ethyl ester 
• 1616-70-2 2-methyl-3-(3-methoxyphenyl)valeric acid 
• 1313429-25-2 2-cyano-3-(3-methoxy-phenyl)-2-methyl-pentanoic acid 
• 1313429-24-1 2-methyl-3-(3-methoxyphenyl)pentanenitrile 

Downstream Products

• 175591-09-0 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol hydrochloride 
• 1243574-48-2 C₂₄H₄₀N₂O₄ 
• 175591-09-0 tapentadol hydrochloride 
• 175591-23-8 tapentadol 
• 1314003-87-6 (rac)-tapentadol-PABA carbamate tert-butyl ester 

Relevant articles and documents

Novel Intermediate Used for Preparing Tapentadol or Analogues Thereof

The invention discloses a novel intermediate for preparing tapentadol and analogues thereof, wherein the structural formula is shown as formula I or II, and the groups are defined as the specification. The invention further discloses a method for preparing the novel intermediate and use of the intermediate for preparing tapentadol and analogues thereof. The invention can remarkably improve the product yield and quality of tapentadol, reduce the production cost, and simplify the production procedure. The preparation process is environment friendly, thus more suitable for the requirements of industrial production.

NOVEL INTERMEDIATE USED FOR PREPARING TAPENTADOL OR ANALOGUES THEREOF

The invention discloses a novel intermediate for preparing tapentadol and analogues thereof, wherein the structural formula is shown as formula I or II, and the groups are defined as the specification. The invention further discloses a method for preparing the novel intermediate and use of the intermediate for preparing tapentadol and analogues thereof. The invention can remarkably improve the product yield and quality of tapentadol, reduce the production cost, and simplify the production procedure. The preparation process is environment friendly, thus more suitable for the requirements of industrial production.

PROCESS FOR PREPARING L-PHENYL-3-DIMETHYLAMINOPROPANE DERIVATIVE

Provided is a process for the preparing l-phenyl-3-dimethylaminopropane derivatives of formula I, (The formula should be inserted here) and its pharmaceutically acceptable salts thereof via novel intermediates.