515135-65-6

Basic information

• Product Name: 5-Bromo-2-fluoro-4-methylbenzoic acid
• Synonyms: 5-Bromo-2-fluoro-4-methylbenzoic acid
• CAS NO: 515135-65-6
• Molecular Formula: C₈H₆BrFO₂
• Molecular Weight: 233.0344432
• Mol File: 515135-65-6.mol
• Article Data: 12

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-Bromo-2-fluoro-4-methylbenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Bromo-2-fluoro-4-methylbenzoic acid(515135-65-6)
• EPA Substance Registry System: 5-Bromo-2-fluoro-4-methylbenzoic acid(515135-65-6)

Safety Data

• Hazardous Substances Data: 515135-65-6(Hazardous Substances Data)

Usage

Description

5-Bromo-2-fluoro-4-methylbenzoic acid is a chemical compound with the molecular formula C8H6BrFO2. It is a derivative of benzoic acid and contains a bromine atom, a fluorine atom, and a methyl group attached to a benzene ring. Its unique molecular structure and properties make it a valuable building block for the production of various complex organic molecules.

Uses

Used in Organic Synthesis:
5-Bromo-2-fluoro-4-methylbenzoic acid is used as a building block for the production of various complex organic molecules. Its functional groups make it a versatile intermediate in the synthesis of various compounds.
Used in Pharmaceutical Research:
5-Bromo-2-fluoro-4-methylbenzoic acid is used as a valuable intermediate in the development of new drugs. Its unique molecular structure and properties make it a promising candidate for pharmaceutical research.
Used in Agrochemicals:
5-Bromo-2-fluoro-4-methylbenzoic acid is used as a versatile intermediate in the synthesis of various agrochemicals, contributing to the development of new and effective products in the agricultural industry.

Upstream product

• 7697-23-6 2-fluoro-4-methylbenzoic Acid 

Downstream Products

• 478374-76-4 5-bromo-2-fluoro-4-methylbenzoic acid methyl ester 

Relevant articles and documents

Targeting KRAS Mutant Cancers via Combination Treatment: Discovery of a Pyridopyridazinone pan-RAF Kinase Inhibitor

Structure-based optimization of a set of aryl urea RAF inhibitors has led to the identification of Type II pan-RAF inhibitor GNE-9815 (7), which features a unique pyrido[2,3-d]pyridazin-8(7H)-one hinge-binding motif. With minimal polar hinge contacts, the pyridopyridazinone hinge binder moiety affords exquisite kinase selectivity in a lipophilic efficient manner. The improved physicochemical properties of GNE-9815 provided a path for oral dosing without enabling formulations. In vivo evaluation of GNE-9815 in combination with the MEK inhibitor cobimetinib demonstrated synergistic MAPK pathway modulation in an HCT116 xenograft mouse model. To the best of our knowledge, GNE-9815 is among the most highly kinase-selective RAF inhibitors reported to date.

GLUCOSE-SENSITIVE ALBUMIN-BINDING DERIVATIVES

This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates. The diboron compounds are characterized by formula (I), which is: R1-X-R2, and wherein "X" is a mono- to multiatomic linker and where R1 and R2, which may be identical or different, each represents a group of Formula (lla) or (IIb) Also described are diboron conjugates represented by the general Formula (I'), which is: R1'-X'-R2', in which either the moeities R1' or R2' or X' carry a drug that is covalently attached to the diboron compound.

PHENYL AMINO PIPERIDINE mTORC INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.