51561-20-7

Basic information

• Product Name: 6-AMINO-2-CHLORO-4-METHYLPYRIDINE-3-CARBONITRILE
• Synonyms: 6-AMINO-2-CHLORO-4-METHYLPYRIDINE-3-CARBONITRILE;3-Pyridinecarbonitrile, 6-aMino-2-chloro-4-Methyl-;6-AMino-2-chloro-4-Methylnicotinonitrile
• CAS NO: 51561-20-7
• Molecular Formula: C₇H₆ClN₃
• Molecular Weight: 167.6
• Mol File: 51561-20-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 375.862°C at 760 mmHg
• Flash Point: 181.115°C
• Appearance: /
• Density: 1.355g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.598
• CAS DataBase Reference: 6-AMINO-2-CHLORO-4-METHYLPYRIDINE-3-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINO-2-CHLORO-4-METHYLPYRIDINE-3-CARBONITRILE(51561-20-7)
• EPA Substance Registry System: 6-AMINO-2-CHLORO-4-METHYLPYRIDINE-3-CARBONITRILE(51561-20-7)

Safety Data

• Hazardous Substances Data: 51561-20-7(Hazardous Substances Data)

Usage

General Description

6-AMINO-2-CHLORO-4-METHYLPYRIDINE-3-CARBONITRILE is a chemical compound with the molecular formula C7H6ClN3. It is a pyridine derivative that contains an amino group, a chlorine atom, a methyl group, and a carbonitrile group. 6-AMINO-2-CHLORO-4-METHYLPYRIDINE-3-CARBONITRILE is used in the pharmaceutical industry as an intermediate for the synthesis of various drugs and pharmaceutical products. Its unique chemical structure and properties make it a valuable building block for the production of active pharmaceutical ingredients. Additionally, it has potential applications in the field of organic synthesis and medicinal chemistry due to its versatile reactivity and functional groups.

InChI:InChI=1/C7H6ClN3/c1-4-2-6(10)11-7(8)5(4)3-9/h2H,1H3,(H2,10,11)

Upstream product

• 875-35-4 2,6-dichloro-4-methylnicotinonitrile 
• 5444-02-0 2,6-dihydroxy-3-cyano-4-methylpyrimidine 

Downstream Products

• 894804-37-6 6-amino-2-ethoxy-4-methylnicotinonitrile 

Relevant articles and documents

SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M4 PAMs

This letter describes progress towards an M4 PAM preclinical candidate inspired by an unexpected aldehyde oxidase (AO) metabolite of a novel, CNS penetrant thieno[2,3-c]pyridine core to an equipotent, non-CNS penetrant thieno[2,3-c]pyrdin-7(6H)-one core. Medicinal chemistry design efforts yielded two novel tricyclic cores that enhanced M4 PAM potency, regained CNS penetration, displayed favorable DMPK properties and afforded robust in vivo efficacy in reversing amphetamine-induced hyperlocomotion in rats.

NEW TRPA1 ANTAGONISTS

The present invention relates to bicyclic heterocyclic derivatives of Forrmula (I), to the process for preparing such compounds and to their use in the treatment of a pathological condition or disease susceptible to amelioration by TRPA1 channel inhibition or antagonism.

Synthesis and Reactivity of 2,6-Diamino-4-methyl-3-pyridinecarbonitrile

2,6-Dihydroxy-4-methyl-3-pyridinecarbonitrile is converted via its 2,6-dichloro analog into the corresponding 2-amino-6-chloro, 2-chloro-6-amino, and 2,6-diamino derivatives.The last reacts with benzenesulfonyl chloride to yield a tris-sulfonyl derivative, the structure of which is demonstrated by X-ray analysis.