51568-18-4 Usage
Description
4,6-Dioxoheptanoic acid, also known as succinylacetone, is a dioxo monocarboxylic acid derived from the heptanoic acid, where oxo groups replace the hydrogens at positions 4 and 6. It is an abnormal metabolite of the tyrosine metabolic pathway and serves as a marker for type 1 tyrosinaemia. This white solid has various applications in different industries due to its unique properties.
Uses
Used in Medical and Diagnostic Applications:
4,6-Dioxoheptanoic acid is used as a specific marker for the inherited metabolic disease, hepatorenal tyrosinemia. It aids in the development of stable-isotope dilution urine tests using a 13C4-SA as an internal standard, which helps in the early detection and monitoring of the disease.
Used in Dendritic Cell Research:
In the field of immunology, 4,6-Dioxoheptanoic acid is used as a component of dendritic cell conditioning medium. It plays a crucial role in the inhibition of ALA dehydratase (ALAD) in dendritic cells, which is essential for understanding the immune response mechanisms.
Used in Heme Biosynthesis Inhibition:
4,6-Dioxoheptanoic acid is employed as an inhibitor of heme biosynthesis in human mononuclear cells and HeLa cells. This application is vital for studying the regulation of heme synthesis and its implications in various diseases and conditions.
Used in Plasmodium falciparum Research:
As a standard for the quantification of succinylacetone from Plasmodium falciparum cultures, 4,6-Dioxoheptanoic acid is utilized in the study of malaria and its metabolic pathways. This application contributes to the development of potential treatments and therapies for malaria.
Biochem/physiol Actions
4,6-Dioxoheptanoic acid is an inhibitor of heme biosynthesis. It is a catabolic byproduct of tyrosine breakdown and inhibits δ-aminolevulinic acid (ALA) dehydratase enzyme. It is a potential marker for detecting tyrosinemia type I and is measured in dried blood spot of new borns.
Check Digit Verification of cas no
The CAS Registry Mumber 51568-18-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,5,6 and 8 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 51568-18:
(7*5)+(6*1)+(5*5)+(4*6)+(3*8)+(2*1)+(1*8)=124
124 % 10 = 4
So 51568-18-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H10O4/c1-5(8)4-6(9)2-3-7(10)11/h2-4H2,1H3,(H,10,11)
