51582-75-3

Basic information

• Product Name: 2-(phenylamino)-5-(trifluoromethyl)benzoic acid
• CAS NO: 51582-75-3
• Molecular Weight: 281.234
• Mol File: 51582-75-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(phenylamino)-5-(trifluoromethyl)benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(phenylamino)-5-(trifluoromethyl)benzoic acid(51582-75-3)
• EPA Substance Registry System: 2-(phenylamino)-5-(trifluoromethyl)benzoic acid(51582-75-3)

Safety Data

• Hazardous Substances Data: 51582-75-3(Hazardous Substances Data)

Upstream product

• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 83265-53-6 2-amino-5-(trifluoromethyl)benzoic acid 
• 657-06-7 2-chloro-5-trifluoromethylbenzoic acid 
• 62-53-3 aniline 

Relevant articles and documents

Chan-Evans-Lam Amination of Boronic Acid Pinacol (BPin) Esters: Overcoming the Aryl Amine Problem

The Chan-Evans-Lam reaction is a valuable C-N bond forming process. However, aryl boronic acid pinacol (BPin) ester reagents can be difficult coupling partners that often deliver low yields, in particular in reactions with aryl amines. Herein, we report effective reaction conditions for the Chan-Evans-Lam amination of aryl BPin with alkyl and aryl amines. A mixed MeCN/EtOH solvent system was found to enable effective C-N bond formation using aryl amines while EtOH is not required for the coupling of alkyl amines.