5161-14-8

Basic information

• Product Name: (2R,5R)-2,5-dimethyltetrahydrothiophene
• Synonyms: (2R,5R)-2,5-Dimethyltetrahydrothiophene; thiophene, tetrahydro-2,5-dimethyl-, (2R,5R)-; Thiophene, tetrahydro-2,5-dimethyl-, trans-
• CAS NO: 5161-14-8
• Molecular Formula: C₆H₁₂S
• Molecular Weight: 116.2245
• Mol File: 5161-14-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 145.3°C at 760 mmHg
• Flash Point: 34.1°C
• Density: 0.906g/cm³
• Vapor Pressure: 6.17mmHg at 25°C
• Refractive Index: 1.474
• CAS DataBase Reference: (2R,5R)-2,5-dimethyltetrahydrothiophene(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,5R)-2,5-dimethyltetrahydrothiophene(5161-14-8)
• EPA Substance Registry System: (2R,5R)-2,5-dimethyltetrahydrothiophene(5161-14-8)

Safety Data

• Hazardous Substances Data: 5161-14-8(Hazardous Substances Data)

Usage

Description

(2R,5R)-2,5-dimethyltetrahydrothiophene is a tetrahydrothiophene derivative with a molecular formula C6H12S. It features a five-membered sulfur-containing ring with two methyl groups attached to the second and fifth carbon atoms. This cyclic thioether is known for its unique structure and reactivity, making it a valuable component in organic synthesis and as a building block for pharmaceuticals and agrochemicals.

Uses

Used in Organic Synthesis:
(2R,5R)-2,5-dimethyltetrahydrothiophene is used as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows for versatile reactions and the formation of a wide range of products.
Used in Pharmaceutical Industry:
(2R,5R)-2,5-dimethyltetrahydrothiophene is used as a building block in the development of new pharmaceuticals. Its reactivity and structural properties contribute to the creation of innovative drugs for various medical applications.
Used in Agrochemical Industry:
(2R,5R)-2,5-dimethyltetrahydrothiophene is also utilized in the agrochemical sector as a component in the synthesis of pesticides, herbicides, and other agricultural chemicals. Its role in these products helps to improve crop yields and protect plants from pests and diseases.
Used in Chemical Industry:
(2R,5R)-2,5-dimethyltetrahydrothiophene is employed across the chemical industry for the development of new compounds with diverse applications. Its unique properties make it a valuable asset in the synthesis of specialty chemicals and materials.

Upstream product

• 54462-67-8 meso-2,5-dibromo-hexane 
• 24774-58-1 2,5-dibromohexane 
• 75937-65-4 2,5-dichloromethylthiophane 
• 109-05-7 2-Methylpiperidin 
• 64-17-5 ethanol 
• 1003-38-9 2,5-dimethyltetrahydrofuran 
• 7783-06-4 hydrogen sulfide 
• 638-02-8 2,5-DIMETHYLTHIOPHENE 

Downstream Products

• 1003-77-6 (+/-)-trans-2,5-dimethyl-tetrahydro-thiophene-1,1-dioxide 

Relevant articles and documents

Reduction of thiophenes in the presence of sulfuric acid and zinc

Alkyl-substituted thiophenes are hydrogenated by the Zn-H 2SO4 system to the corresponding 2,5-di- hydrothiophenes and thiophanes. In the case of 2-formyl- and 2-acetylthiophene it was established that in substituted thiophenes simul

FORMATION OF SULPHUR COMPOUNDS IN THE HYDRODENITROGENATION OF 2-METHYLQUINOLINE, 2-METHYLPIPERIDINE, INDOLE, AND ISOQUINOLINE ON A NICKEL-TUNGSTEN CATALYST IN THE PRESENCE OF HYDROGEN SULPHIDE

2-Methylquinoline, 2-methylpiperidine, indole, and isoquinoline were subjected to hydrodenitrogenation (HDN) on a sulphidized nickel-tungsten catalyst in an autoclave at 300 and 350 deg C using pure hydrogen or a hydrogen-hydrogen sulphide mixture.The neutral fraction from the HDN of 2-methylquinoline and 2-methylpiperidine contained 40 and 90percent sulphur compounds, respectively.The presence of hydrogen sulphide in the HDN of isoquinoline resulted in an enhanced fraction of the neutral moiety.A reaction mechanism is suggested for the HDN of 2-methylquinoline and 2-methylpiperidine in the presence of hydrogen sulphide, in which the latter contributes to the higher degree of conversion due to the formation of corresponding sulphur compounds.