51627-47-5

Basic information

• Product Name: 2-MORPHOLINO-3-PYRIDINAMINE
• Synonyms: BUTTPARK 98\12-74;2-MORPHOLINO-3-PYRIDINAMINE;2-MORPHOLIN-4-YL-PYRIDIN-3-YLAMINE;AKOS B034185;3-Amino-2-morpholin-4-ylpyridine;2-Morpholinopyridin-3-amine
• CAS NO: 51627-47-5
• Molecular Formula: C₉H₁₃N₃O
• Molecular Weight: 179.22
• Mol File: 51627-47-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 127-129°C
• Boiling Point: 381.9 °C at 760 mmHg
• Flash Point: 184.8 °C
• Appearance: /
• Density: 1.208 g/cm³
• Vapor Pressure: 4.91E-06mmHg at 25°C
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-MORPHOLINO-3-PYRIDINAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-MORPHOLINO-3-PYRIDINAMINE(51627-47-5)
• EPA Substance Registry System: 2-MORPHOLINO-3-PYRIDINAMINE(51627-47-5)

Safety Data

• Hazard Codes: Xi
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.; R36/37/38:Irritating to eyes, respiratory system
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• HazardClass: IRRITANT
• Hazardous Substances Data: 51627-47-5(Hazardous Substances Data)

Usage

General Description

2-Morpholino-3-pyridinamine is a chemical compound that belongs to the class of organic compounds known as pyridines and derivatives. It is a heterocyclic amine that contains a morpholine ring and a pyridine ring. 2-MORPHOLINO-3-PYRIDINAMINE has potential pharmacological properties and may be used in the development of drugs. It has a variety of potential applications, particularly in the field of medicinal chemistry. The exact properties and uses of 2-morpholino-3-pyridinamine may vary depending on its specific chemical structure and characteristics, but it is likely to have potential as a therapeutic agent or as a precursor in the synthesis of pharmaceuticals.

InChI:InChI=1/C9H13N3O/c10-8-2-1-3-11-9(8)12-4-6-13-7-5-12/h1-3H,4-7,10H2/p+1

Upstream product

• 24255-27-4 4-(3-nitropyridin-2-yl)morpholine 
• 110-91-8 morpholine 
• 6298-19-7 2-chloro-3-aminopyridine 
• 39856-57-0 2,6-dibromo-3-aminopyridine 
• 5470-18-8 2-Chloro-3-nitropyridine 

Relevant articles and documents

HDAC inhibitor and preparation method and application thereof

The present invention discloses a compound represented by a formula I, a stereoisomer thereof, and a pharmaceutically acceptable salt thereof. The invention further relates to a pharmaceutical composition containing the compound shown in the formula I and application of the compound in preparation of HDAC inhibitor drugs. The compound or the pharmaceutical composition thereof can be used for treating cell proliferation diseases, autoimmune diseases, inflammation, neurodegenerative diseases or viral diseases.

Process for preparing 4-(5-bromine-3-fluoropyridine-2-yl) morpholine

The invention discloses a process for preparing 4-(5-bromine-3-fluoropyridine-2-yl) morpholine. The process comprises the following steps: (1) by taking 2-chlorine-3-nitropyridine as a raw material, performing a substitution reaction so as to generate 4-(3-nitropyridine-2-yl) morpholine; (2) performing a reduction reaction on 4-(3-nitropyridine-2-yl) morpholine to generate 2-morpholino pyridine-3-amine; (3) performing diazotization and substation reactions on 2-morpholino pyridine-3-amine to generate 4-(3-fluorine pyridine-2-yl) morpholine; and (4) performing a substitution reaction on 4-(3-fluorine pyridine-2-yl) morpholine, thereby obtaining a target compound, namely 4-(5-bromine-3-fluoropyridine-2-yl) morpholine. By adopting the process, raw materials are cheap and easy to obtain, operation conditions are gentle and easy to control, products are relatively easy to purify, and practical application can be facilitated.

The synthesis of 3-amino-2-dialkylaminopyridines

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