51632-37-2

Basic information

• Product Name: diethyl 2-phenyl-2-(prop-2-yn-1-yl)malonate
• Synonyms: diethyl 2-phenyl-2-(prop-2-yn-1-yl)malonate
• CAS NO: 51632-37-2
• Molecular Weight: 274.317
• Mol File: 51632-37-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: diethyl 2-phenyl-2-(prop-2-yn-1-yl)malonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl 2-phenyl-2-(prop-2-yn-1-yl)malonate(51632-37-2)
• EPA Substance Registry System: diethyl 2-phenyl-2-(prop-2-yn-1-yl)malonate(51632-37-2)

Safety Data

• Hazardous Substances Data: 51632-37-2(Hazardous Substances Data)

Upstream product

• 106-96-7 propargyl bromide 
• 83-13-6 diethyl 2-phenylmalonate 

Downstream Products

• 51632-38-3 2-phenyl-pent-4-ynoic acid 
• 1246522-09-7 2-phenyl-2-(3-phenyl-prop-2-ynyl)-malonic acid diethyl ester 
• 1262883-65-7 diethyl 2-(2-iodoallyl)-2-phenylmalonate 
• 1251414-59-1 2,9-bis-ethoxycarbonyl-2,9-diphenyl-dec-4-en-6-ynedioic acid diethyl ester 
• 91973-41-0 2-(1-phenyl-but-3-ynyl)-[1,3,4]oxadiazole 
• 91350-21-9 2-phenyl-pent-4-ynoic acid hydrazide 
• 91962-89-9 methyl 2-phenylpent-4-ynoate 
• 91063-81-9 Chlorid d. α-Propargyl-phenylessigsaeure 
• 94971-48-9 Propargyl-phenyl-malonsaeure 

Relevant articles and documents

An Enantioselective Iodolactonization/Cross-Coupling Protocol for the Synthesis of Highly Substituted Enol Lactones

γ-Alkynoic acids readily undergo iodolactonization to give iodoenol lactones. Using commercially available (DHQD)2PHAL this transformation can be rendered asymmetric. In desymmetrization reactions of dialkynoic acids, good to very good enantioselectivities can be observed. Alternatively, kinetic resolution of already chiral, racemic γ-alkynoic acids can be carried out. The products of these iodolactonizations, iodoenol lactones, are suitable substrates for Palladium catalyzed cross-couplings. Negishi- as well as Sonogashira couplings can be carried out and allow the efficient synthesis of highly substituted enol lactones.