51646-19-6

Basic information

• Product Name: 5,7-DIMETHYL-2-(METHYLSULFANYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE
• Synonyms: 5,7-DIMETHYL-2-(METHYLSULFANYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE;[1,2,4]Triazolo[1,5-a]pyrimidine, 5,7-dimethyl-2-(methylthio)-
• CAS NO: 51646-19-6
• Molecular Formula: C8H10N4S
• Molecular Weight: 194.26
• Mol File: 51646-19-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• PKA: 1.29±0.30(Predicted)
• CAS DataBase Reference: 5,7-DIMETHYL-2-(METHYLSULFANYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-DIMETHYL-2-(METHYLSULFANYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE(51646-19-6)
• EPA Substance Registry System: 5,7-DIMETHYL-2-(METHYLSULFANYL)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE(51646-19-6)

Safety Data

• Hazardous Substances Data: 51646-19-6(Hazardous Substances Data)

Upstream product

• 51646-17-4 5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine-2-thiol 
• 74-88-4 methyl iodide 
• 815-68-9 3-acetylpentane-2,4-dione 
• 45534-08-5 5-amino-3-methylthio-1,2,4-triazole 
• 123-54-6 acetylacetone 
• 63422-02-6 dithiophosphoric acid S-(2-bromo-ethyl ester)-O,O'-dimethyl ester 
• 45534-08-5 5-methylsulfanyl-2H-[1,2,4]triazol-3-ylamine 

Downstream Products

• 1609980-39-3 2-[2-(4-chlorophenoxy)ethoxy]-5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidine 
• 1609980-41-7 2-{[2-({5,7-dimethyl[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}oxy)ethyl](phenyl)amino}ethan-1-ol 

Relevant articles and documents

Syntheses and biological activities of S-1,2,4-triazolo[1,5-a]pyrimidinylalkyl dithiophosphates

We introduced dithiophosphate moieties into the fused heterocyclic compound to prepare the title derivatives and characterized their structures by elemental analysis, 1H NMR, and IR spectral data. We found that these compounds show good fungicidal and herbicidal activities and good plant growth regulation activity.

SUBSTITUTED TRIAZOLO-PYRIMIDINE COMPOUNDS FOR MODULATING CELL PROLIFERATION, DIFFERENTIATION AND SURVIVAL

Disclosed herein are erythropoietin-mimetic compounds of Formula I, which modulate the survival, function, or differentiation of, for example, kidney cells, neurons, erythroid cells, or other erythropoietin-responsive cells. The present invention also relates to compounds and methods that preferentially modulate cells expressing the tissue-protective erythropoietin receptor. The compounds of the invention are useful in preventing and treating diseases, such as anemia, organ injury, and diseases of the central nervous system, and as an adjunct to cellular treatments, such as stem cell therapies.

2-(Alkylthio)-1,2,4-triazolo[1,5-a]pyrimidines as adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitors with potential as new cardiovascular agents

A series of new 2-(alkylthio)-5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidines have been prepared as inhibitors of cAMP phosphodiesterase from various tissues. These derivatives were prepared via ring closure of various requisite 3-amino-1,2,4-triazole