516481-68-8

Basic information

• Product Name: 2-Pyridinecarbonitrile,5,6-diamino-(9CI)
• Synonyms: 2-Pyridinecarbonitrile,5,6-diamino-(9CI)
• CAS NO: 516481-68-8
• Molecular Formula: C₆H₆N₄
• Molecular Weight: 134.13864
• Product Categories: PYRIDINE
• Mol File: 516481-68-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Pyridinecarbonitrile,5,6-diamino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinecarbonitrile,5,6-diamino-(9CI)(516481-68-8)
• EPA Substance Registry System: 2-Pyridinecarbonitrile,5,6-diamino-(9CI)(516481-68-8)

Safety Data

• Hazardous Substances Data: 516481-68-8(Hazardous Substances Data)

Upstream product

• 516481-67-7 6-amino-5-nitro-pyridine-2-carbonitrile 
• 38533-61-8 2-chloro-6-methoxy-3-nitropyridine 
• 73896-36-3 6-methoxy-3-nitropyridin-2-amine 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 
• 211555-30-5 2-amino-3-nitro-6-hydroxypyridine 

Downstream Products

• 883560-08-5 2-[4-(4-chloro-phenoxy)-phenyl]-3H-imidazo[4,5-b]pyridine-5-carbonitrile 
• 516481-65-5 2-[4-(3,4-Dichloro-phenoxy)-phenyl]-1H-imidazo[4,5-b]pyridine-5-carboxylic Acid Amide 

Relevant articles and documents

Methods for Chk2 inhibitor patient selection

The present invention contemplates a method to identify subjects that either have a tumor, or are at risk for tumor development, that are responsive to various inhibitors of an activated-Chk2 protein. Such Chk2 inhibitors may comprise a benzimidazole core structure, and derivatives thereof. Other Chk2 inhibitors may comprise nucleic acids, such as silencing interference RNA's specific for a Chk2 expression. Other Chk2 inhibitors may comprises proteins, such as antibodies. For example, the present invention contemplates that when a Chk2 inhibitor is administered during, or after, ionizing radiation tumor cell apoptosis is increased.

Substituted benzimidazoles and imidazo-[4,5]-pyridines

2-Aryl substituted benzimidazoles and imidazo[4,5]pyridines are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer.