51650-21-6

Basic information

• Product Name: 2,4-dimethyl-5-phenyl-4,5-dihydro-oxazole
• Synonyms: 2,4-dimethyl-5-phenyl-4,5-dihydro-oxazole
• CAS NO: 51650-21-6
• Molecular Weight: 175.23
• Mol File: 51650-21-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,4-dimethyl-5-phenyl-4,5-dihydro-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dimethyl-5-phenyl-4,5-dihydro-oxazole(51650-21-6)
• EPA Substance Registry System: 2,4-dimethyl-5-phenyl-4,5-dihydro-oxazole(51650-21-6)

Safety Data

• Hazardous Substances Data: 51650-21-6(Hazardous Substances Data)

Upstream product

• 100129-44-0 (+/-)-2ξ-chloro-2ξ,4r-dimethyl-5c-phenyl-oxazolidine; hydrochloride 
• 81703-28-8 N-<(1R,2S)-(-)-norephedrine>methylamide 
• 3509-76-0 (+/-)-N-acetylnorephedrine 
• 926-67-0 O-Ethyl thioacetate 
• 14838-15-4 u-2-amino-1-phenylpropan-1-ol 
• 3509-76-0 1-hydroxy-1-phenyl-2-(acetylamino)propane 
• 54680-46-5 norephedrine 

Downstream Products

• 126188-49-6 (1S,2S)-N-<(2-Hydroxy-2-phenyl)-1-methyl-ethyl>-acetamid 

Relevant articles and documents

(DIETHYLAMINO)SULFUR TRIFLUORIDE (DAST) AS A USEFUL REAGENT FOR THE PREPARATION OF 2-OXAZOLINES FROM 1,2-AMIDO ALCOHOLS

Acylic 1,2-amido alcohols (6) react efficiently with a slight excess of (diethylamino)sulfur trifluoride (DAST) to afford the corresponding 2-oxazolines (10) in good yields ranging between 57-95percent.Even at the low temperature of -78 deg C, a rapid ( 1 h) and stereoselective amide cyclization is observed without formation of acylaziridine by-products.The scope of this cyclization is discussed.