51674-77-2

Basic information

• Product Name: Pyrido[3,2-d]pyrimidine, 4-chloro-
• Synonyms: Pyrido[3,2-d]pyrimidine, 4-chloro-;4-chloropyrido[3,2-d]pyrimidine;4-Chloropyrido[3,2-d]pyri...;4-chloropyrido[3
• CAS NO: 51674-77-2
• Molecular Formula: C₇H₄ClN₃
• Molecular Weight: 165.57976
• Product Categories: CHIRAL CHEMICALS;Heterocycle-Pyrimidine series
• Mol File: 51674-77-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 136-139 °C (decomp)
• Boiling Point: 297.293 °C at 760 mmHg
• Flash Point: 161.721 °C
• Appearance: /
• Density: 1.438 g/cm³
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.675
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.08±0.30(Predicted)
• CAS DataBase Reference: Pyrido[3,2-d]pyrimidine, 4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrido[3,2-d]pyrimidine, 4-chloro-(51674-77-2)
• EPA Substance Registry System: Pyrido[3,2-d]pyrimidine, 4-chloro-(51674-77-2)

Safety Data

• Hazardous Substances Data: 51674-77-2(Hazardous Substances Data)

Usage

General Description

Pyrido[3,2-d]pyrimidine, 4-chloro- is a chemical compound with the molecular formula C7H5ClN4. It is a heterocyclic aromatic compound that consists of a pyrido[3,2-d]pyrimidine ring system with a chlorine atom attached at the 4-position. Pyrido[3,2-d]pyrimidine, 4-chloro- is widely used in the pharmaceutical and agrochemical industries as a building block for the synthesis of various biologically active molecules and pesticides. It has also been studied for its potential antitumor and antiviral properties. Pyrido[3,2-d]pyrimidine, 4-chloro- is known for its role as an important intermediate in organic synthesis and has gained significant attention in the field of medicinal chemistry for drug discovery and development.

InChI:InChI=1/C7H4ClN3/c8-7-6-5(10-4-11-7)2-1-3-9-6/h1-4H

Upstream product

• 37538-67-3 pyrido[3,2-d]-pyrimidin-4(3H)-one 
• 50608-99-6 3-amino-pyridine-2-carboxylic acid amide 
• 93683-65-9 6-chloro-3-nitropicolinonitrile 
• 171178-21-5 6-chloro-3-nitropyridine-2-carboxamide 
• 1462-86-8 3-amino-pyridine-2-carboxylic acid 
• 37538-67-3 4-hydroxy-pyrido[3,2-d]pyrimidine 

Downstream Products

• 51674-90-9 4-hydrazinopyrido(3,2-d)pyrimidine 
• 50608-99-6 3-amino-pyridine-2-carboxylic acid amide 
• 171347-62-9 4-anilinopyrido[3,2-d]pyrimidine mesylate 
• 1304513-59-4 2-(pyrido[3,2-d]pyrimidin-4-ylamino)benzoic acid 
• 1362850-22-3 N-[(R)-1-(8-chloro-2-phenylquinolin-3-yl)-2,2,2-trifluoroethyl]pyrido[3,2-d]pyrimidin-4-ylamine 
• 1420618-60-5 C₂₈H₂₃N₇O 
• 1420619-03-9 C₂₉H₂₃N₇O 
• 1420618-39-8 C₂₄H₁₈ClN₅O 

Relevant articles and documents

Syntheses of Some Azolopyridopyrimidines

Syntheses of isomeric azolopyridopyrimidines are described.As starting material the corresponding pyridopyrimidines were used.It could be established that in many cases a transformation of a functional group with the purpose to form an annelated five-membered ring proceeded with ring opening at the pyrimidine part.Subsequent ring closure with one carbon synthons gave then the desired tricyclic heterocycles. - Keywords: Cyclization with C-N and N-N bond formation; Tricyclic heterocyclic compounds

HETEROCYCLIC COMPOUNDS AND USES THEREOF

Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

Bicyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

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