51719-84-7

Basic information

• Product Name: 5-Phenyl-1H-1,2,3-triazole-4-carbaldehyde
• Synonyms: 5-Phenyl-1H-1,2,3-triazole-4-carbaldehyde;5-phenyl-2H-triazole-4-carbaldehyde
• CAS NO: 51719-84-7
• Molecular Formula: C₉H₇N₃O
• Molecular Weight: 173.1714
• Mol File: 51719-84-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 430.4 °C at 760 mmHg
• Flash Point: 215.1 °C
• Appearance: /
• Density: 1.32 g/cm³
• Vapor Pressure: 1.3E-07mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: 5-Phenyl-1H-1,2,3-triazole-4-carbaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Phenyl-1H-1,2,3-triazole-4-carbaldehyde(51719-84-7)
• EPA Substance Registry System: 5-Phenyl-1H-1,2,3-triazole-4-carbaldehyde(51719-84-7)

Safety Data

• Hazardous Substances Data: 51719-84-7(Hazardous Substances Data)

Usage

General Description

5-Phenyl-1H-1,2,3-triazole-4-carbaldehyde is an organic compound with the chemical formula C10H7N3O. It is a member of the 1,2,3-triazole family, which is a class of nitrogen-containing heterocycles. This specific compound contains a phenyl group and a carbonyl aldehyde functional group attached to a 1,2,3-triazole ring. It has potential applications in the field of medicinal chemistry, as 1,2,3-triazoles have been found to exhibit diverse biological activities and pharmacological properties. 5-Phenyl-1H-1,2,3-triazole-4-carbaldehyde may also be used as a building block in the synthesis of various organic molecules and materials due to its unique structural features.

InChI:InChI=1/C9H7N3O/c13-6-8-9(11-12-10-8)7-4-2-1-3-5-7/h1-6H,(H,10,11,12)

Upstream product

• 2579-22-8 Phenylpropargyl aldehyde 
• 84452-21-1 2-hydroxy-4-phenyl-3-butynenitrile 
• 665012-61-3 1,5-diallyl-4-phenyl-1H-1,2,3-triazole 
• 6142-95-6 phenylpropargyl aldehyde diethyl acetal 
• 536-74-3 phenylacetylene 
• 165397-46-6 Phenyl-[1-(5-phenyl-3H-[1,2,3]triazol-4-yl)-meth-(E)-ylidene]-amine 
• 82671-74-7 N-benzylidene(phenylethynyl)amine 
• 125454-66-2 N-(3-phenylprop-2-yn-1-ylidene)-t-butylamine 

Downstream Products

• 830-78-4 4-carboxyl-5-phenyl-1,2,3-triazole 

Relevant articles and documents

Synthesis of 1,3-dioxacyclan-2-yl-substituted 1,2,3-triazoles

A new method for preparing 4-(1,3-dioxacyclan-2-yl)-5-phenyl-1,2,3-triazoles in 30–75% yields has been developed on the basis of azide–alkyne cycloaddition to 2-phenylethinyl-1,3-dioxacyclanes. It has been shown that the best results are achieved when the reaction is carried out at 150–155°C in DMSO.

CYCLOADDITION OF HYDRAZOIC ACID TO α,β-ACETYLENIC ALDIMINES

The selectivity of the reaction of hydrazoic acid with α,β-acetylenic aldimines R1CCCH=NR2 was found to be independent of the nature of the substituents R1 and R2: in all the cases studied the addition occurs

REACTION OF ACETYLENE NITRILES WITH AZIDES

The addition of organic and inorganic azides to 3-phenylpropynenitrile and 4-phenyl-2-hydroxy-3-butynenitrile was investigated.It was shown that organic azides add to 3-phenylpropynenitrile exclusively at the triple bond.The reaction with aluminum azide takes place with the participation of the acetylene bond and the nitrile group.The reaction of 4-phenyl-2-hydroxy-3-butynenitrile with azides is accompanied by decomposition to phenylpropargylaldehyde with the subsequent formation of 4-formyl-1,2,3-triazole.The oxidation of 4-phenyl-2-hydroxy-3-butynenitrile withactive manganese dioxide with the simultaneous addition of the azides leads to the formation of 4-carboxy-5-phenyl-1,2,3-triazole.