51720-37-7Relevant articles and documents
2-(1H-Imidazol-4-yl)ethanamine and 2-(1H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924
Saulnier, Mark G.,Frennesson, David B.,Wittman, Mark D.,Zimmermann, Kurt,Velaparthi, Upender,Langley, David R.,Struzynski, Charles,Sang, Xiaopeng,Carboni, Joan,Li, Aixin,Greer, Ann,Yang, Zheng,Balimane, Praveen,Gottardis, Marco,Attar, Ricardo,Vyas, Dolatrai
, p. 1702 - 1707 (2008/09/20)
A series of IGF-1R inhibitors is disclosed, wherein the (m-chlorophenyl)ethanol side chain of BMS-536924 (1) is replaced with a series of 2-(1H-imidazol-4-yl)ethanamine and 2-(1H-pyrazol-1-yl)ethanamine side chains. Some analogs show improved IGF-1R poten
A Heteroditopic Hexa-imidazole 'Encapsulating' Podand and a Facially Differentiated Hexadentate Ligand
Potvin, Pierre G.,Wong, Man Hung
, p. 672 - 674 (2007/10/02)
Syntheses of the facially differentiated tris-imidazole triamine (10) and of the novel 'hetero'-ditopic hexa-imidazole ligand (11), from histamine (3), are described.