5174-87-8

Basic information

• Product Name: Ketone, methyl 2-methyl-1,8-naphthyridin-3-yl
• Synonyms: Ketone, methyl 2-methyl-1,8-naphthyridin-3-yl;1-(2-methyl-1,8-naphthyridin-3-yl)ethanone
• CAS NO: 5174-87-8
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.21
• Mol File: 5174-87-8.mol
• Article Data: 12

Chemical Properties

• Melting Point: 146-147 °C
• Boiling Point: 317.5°Cat760mmHg
• Flash Point: 150.2°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0.000384mmHg at 25°C
• Refractive Index: 1.615
• PKA: 2.47±0.30(Predicted)
• CAS DataBase Reference: Ketone, methyl 2-methyl-1,8-naphthyridin-3-yl(CAS DataBase Reference)
• NIST Chemistry Reference: Ketone, methyl 2-methyl-1,8-naphthyridin-3-yl(5174-87-8)
• EPA Substance Registry System: Ketone, methyl 2-methyl-1,8-naphthyridin-3-yl(5174-87-8)

Safety Data

• Hazardous Substances Data: 5174-87-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C11H10N2O/c1-7-10(8(2)14)6-9-4-3-5-12-11(9)13-7/h3-6H,1-2H3

Upstream product

• 7521-41-7 2-Aminonicotinaldehyde 
• 123-54-6 acetylacetone 

Downstream Products

• 119496-42-3 (E)-1-(2-Methyl-[1,8]naphthyridin-3-yl)-3-p-tolyl-propenone 
• 119496-44-5 (E)-3-(4-Chloro-phenyl)-1-(2-methyl-[1,8]naphthyridin-3-yl)-propenone 
• 119496-48-9 (E)-1-(2-Methyl-[1,8]naphthyridin-3-yl)-3-(3-nitro-phenyl)-propenone 
• 119496-39-8 (E)-1-(2-Methyl-[1,8]naphthyridin-3-yl)-3-phenyl-propenone 
• 119496-41-2 (E)-3-(4-Methoxy-phenyl)-1-(2-methyl-[1,8]naphthyridin-3-yl)-propenone 
• 119496-45-6 (E)-3-(2-Hydroxy-phenyl)-1-(2-methyl-[1,8]naphthyridin-3-yl)-propenone 
• 119496-46-7 (E)-3-(4-Hydroxy-3-methoxy-phenyl)-1-(2-methyl-[1,8]naphthyridin-3-yl)-propenone 

Relevant articles and documents

Synthesis method of 1,8-naphthyridine derivative

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method of a 1,8-naphthyridine derivative. The synthesis method comprises the following steps: under the protection of nitrogen, subjecting 2-amino-3

ZrOClinf2/inf.8Hinf2/infO catalyzed solvent-free Friedlander synthesis of 1,8-naphthyridines

ZrOClinf2/inf.8Hinf2/infO catalyzed Friedlander condensation of 2-Aminonicotinaldehyde 1 with carbonyl compounds containing-methylene group 2 has been achieved in solvent-free grinding conditions to give 1,8-naphthyridines 3. The yields are very good and

Green approach for the efficient synthesis of 1,8-naphthyridines promoted by citric acid

Citric acid catalyzed Friedlander condensation of 2-aminonicotinaldehyde 1 with various carbonyl compounds containing α-methylene group 2 has been achieved under neat conditions at 100° to give the corresponding 1,8-naphthyridines 3. The products are obta