51760-22-6

Basic information

• Product Name: 5-BROMO-1,3-DIHYDROXYMETHYLBENZENE
• Synonyms: 5-BROMO-1,3-DIHYDROXYMETHYLBENZENE;1,3-BenzenediMethanol, 5-broMo-;(5-BroMo-1,3-phenylene)diMethanol;5-BroMo-3-(hydroxyMethyl)benzyl alcohol;5-bromo-1,3-benzenedimethanol;(3-Bromo-5-hydroxymethyl-phenyl)-methanol;(5-Bromo-1,3-phenylene)
• CAS NO: 51760-22-6
• Molecular Formula: C₈H₉BrO₂
• Molecular Weight: 217.05986
• EINECS: 200-258-5
• Mol File: 51760-22-6.mol
• Article Data: 19

Chemical Properties

• Melting Point: 90-91 °C
• Boiling Point: 369.0±32.0 °C(Predicted)
• Appearance: /
• Density: 1.628±0.06 g/cm3(Predicted)
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 13.91±0.10(Predicted)
• CAS DataBase Reference: 5-BROMO-1,3-DIHYDROXYMETHYLBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-1,3-DIHYDROXYMETHYLBENZENE(51760-22-6)
• EPA Substance Registry System: 5-BROMO-1,3-DIHYDROXYMETHYLBENZENE(51760-22-6)

Safety Data

• Hazardous Substances Data: 51760-22-6(Hazardous Substances Data)

Usage

General Description

5-Bromo-1,3-dihydroxymethylbenzene, also known as veratrole bromohydrin, is an organic compound that belongs to the class of phenols. This chemical compound is a light yellow solid that appears as crystals. The presence of bromine and two hydroxy groups in its structure makes it a valuable intermediate for various organic syntheses. It appears with molecular formula C7H7BrO3, whose properties involve an aromatic benzene ring substituted by a bromine atom and two hydroxymethyl groups. The substance is sparingly soluble in water but can dissolve in organic solvents like ethanol and acetone. It's primarily used in research and development, pharmaceutical manufacturing, and specialty chemical production. It's essential in the synthesis of complex organic molecules and polymers.

Upstream product

• 51760-21-5 dimethyl 5-bromoisophthalate 
• 23351-91-9 5-bromoisophthalic acid 
• 121-91-5 isophthalic acid 
• 99-27-4 dimethyl 5-aminoisophthalate 
• 556-96-7 5-bromo-1,3-xylene 
• 51760-23-7 1-bromo-3,5-bis(bromomethyl)benzene 
• 1374658-80-6 dimethyl 2,2′-(5-bromo-1,3-phenylene)diacetate 

Downstream Products

• 120173-41-3 5-bromobenzene-1,3-dicarbaldehyde 
• 137334-69-1 1-bromo-3,5-bis(methoxymethyl)benzene 
• 181225-40-1 [[(5-bromo-1,3-phenylene)bis(methylene)]bis(oxy)]bis(tert-butyldimethylsilane) 
• 636984-39-9 C₂₈H₂₅BrO₁₀ 
• 636984-40-2 {3-[3-(3,5-bis-hydroxymethyl-phenoxymethyl)-5-bromo-benzyloxy]-5-hydroxymethyl-phenyl}-methanol 
• 263746-70-9 5-ethynyl-1,3-benzenedicarboxaldehyde 
• 263746-69-6 1,3-Bisformyl-5-trimethylsilylacetylenebenzene 
• 263746-71-0 m,m'-bisformylbenzene-4-ethynyl-benzaldehyde 
• 263746-74-3 C₂₀H₂₉BrN₄O₂ 
• 263746-67-4 1,3-bis(1,3-dihydroxy-4,4,5,5-tetramethylimidazolin-2-yl)-5-bromobenzene 
• 263746-66-3 C₃₅H₄₃N₆O₄ 
• 263746-68-5 C₃₅H₅₂N₆O₆ 
• 220096-20-8 1-Bromo-3,5-bis(dimethoxymethyl)benzene 
• 220096-40-2 1,2-bis[di(3',5'-diformylphenyl)phosphanyl]ethane 

Relevant articles and documents

Structure-Activity Studies with Bis-Amidines That Potentiate Gram-Positive Specific Antibiotics against Gram-Negative Pathogens

Pentamidine, an FDA-approved antiparasitic drug, was recently identified as an outer membrane disrupting synergist that potentiates erythromycin, rifampicin, and novobiocin against Gram-negative bacteria. The same study also described a preliminary structure-activity relationship using commercially available pentamidine analogues. We here report the design, synthesis, and evaluation of a broader panel of bis-amidines inspired by pentamidine. The present study both validates the previously observed synergistic activity reported for pentamidine, while further assessing the capacity for structurally similar bis-amidines to also potentiate Gram-positive specific antibiotics against Gram-negative pathogens. Among the bis-amidines prepared, a number of them were found to exhibit synergistic activity greater than pentamidine. These synergists were shown to effectively potentiate the activity of Gram-positive specific antibiotics against multiple Gram-negative pathogens such as Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli, including polymyxin- and carbapenem-resistant strains.

MULTICYCLIC PEPTIDES AND METHODS FOR THEIR PREPARATION

The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.

ZINC COMPLEX

A zinc complex characterized in exhibiting an octahedral structure and being configured from repeating units represented by general formula (I): wherein L represents a linker region, and R1 represents a C1-4 alkyl group, which can have a halogen atom.