51762-51-7

Basic information

• Product Name: BENZHYDRYL 3-HYDROXY-7-(PHENYLACETAMIDO)CEPHAM-4-CARBOXYLATE
• Synonyms: BENZHYDRYL 3-HYDROXY-7-(PHENYLACETAMIDO)CEPHAM-4-CARBOXYLATE;Ceftibuten Related Impurity 4;(6S)-benzhydryl 3-hydroxy-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]octane-2-carboxylate
• CAS NO: 51762-51-7
• Molecular Formula: C₂₈H₂₆N₂O₅S
• Molecular Weight: 502.58
• Mol File: 51762-51-7.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 775.7±60.0 °C(Predicted)
• Appearance: /
• Density: 1.39±0.1 g/cm3(Predicted)
• PKA: 12.81±0.60(Predicted)
• CAS DataBase Reference: BENZHYDRYL 3-HYDROXY-7-(PHENYLACETAMIDO)CEPHAM-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: BENZHYDRYL 3-HYDROXY-7-(PHENYLACETAMIDO)CEPHAM-4-CARBOXYLATE(51762-51-7)
• EPA Substance Registry System: BENZHYDRYL 3-HYDROXY-7-(PHENYLACETAMIDO)CEPHAM-4-CARBOXYLATE(51762-51-7)

Safety Data

• Hazardous Substances Data: 51762-51-7(Hazardous Substances Data)

Usage

General Description

Benzhydryl 3-hydroxy-7-(phenylacetamido)cepham-4-carboxylate is a chemical compound that is a derivative of cephem and has a benzhydryl group and phenylacetamido group attached to its structure. It is a cephalosporin antibiotic, which means it has the ability to inhibit the growth of bacteria by interfering with the formation of their cell walls. BENZHYDRYL 3-HYDROXY-7-(PHENYLACETAMIDO)CEPHAM-4-CARBOXYLATE has potential therapeutic uses in the treatment of bacterial infections, particularly those caused by Gram-positive and some Gram-negative bacteria. However, further research and testing are needed to fully understand and harness its medicinal properties.

Upstream product

• 84532-30-9 3-hydroxy-7-phenylacetamido-3-cephem-4-carboxylic acid benzhydrylester 
• 51762-03-9 (6R)-3-methylene-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid benzhydryl ester 
• 859-07-4 cephaloram 
• 54240-49-2 (6R)-3-methylene-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 
• 54639-48-4 (6R,7R)-benzhydryl 3-hydroxy-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 

Downstream Products

• 51795-12-1 (6R)-3ξ-acetoxy-8-oxo-7t-(2-phenyl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2ξ-carboxylic acid benzhydryl ester 
• 36923-19-0 diphenylmethyl (6R,7R)-7-(phenylacetamido)ceph-3-em-4-carboxylate 
• 103002-48-8 3-methanesulfonyloxy-7beta-phenylacetylaminocepham-4-carboxylic acid diphenylmethyl ester 
• 102995-03-9 3-p-toluenesulfonyloxy-7beta-phenylacetylaminocepham-4-carboxylic acid diphenylmethyl ester 
• 36923-21-4 diphenylmethyl 7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 51761-90-1 diphenylmethyl 7-amino-3-hydroxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 

Relevant articles and documents

Method for preparing ceftibuten mother nucleus 7-ANCE

The invention belongs to a method for preparing a ceftibuten mother nucleus 7-ANCE. The method for preparing the ceftibuten mother nucleus 7-ANCE comprises the following steps: S1, reacting a compound A as shown in a formula I with halogenated phosphorus and an acid-binding agent; S2, adding an acid solution to react to generate ammonium salt; and S3, adjusting the pH value of the ammonium salt generated in the step S2 to be neutral or alkaline to obtain a crude product, and purifying to obtain the ceftibuten mother nucleus 7-ANCE, wherein the molar ratio of the compound A to the halogenated phosphorus is 1: (2.5-3.5). Compared with the prior art, the method has the beneficial effects that the reaction is carried out in the rearrangement direction by controlling the molar ratio of the compound A to the phosphorus halide, so that the hydroxyl protection step in the prior art can be omitted, the use of a methylsulfonyl chloride irritant raw material is avoided, and a product with higher purity and yield is obtained.

7β-Amino-cepham-3-ol-4-carboxylic acid compounds

The invention concerns 7β-amino-cepham-3-ol-4-carboxylic acid compounds, particularly esters thereof, and the N-substituted, especially N-acylated derivatives of such compounds, as well as the 3-O-esters of these compounds. They can be used as intermediates, for example, for the manufacture of the corresponding 3-unsubstituted 7β-amino-3-cephem-4-carboxylic acid compounds, which show outstanding pharmacological effects.