51771-30-3Relevant articles and documents
Antimicrobial Activity of N-(3-Chloro-2-aryl-4-oxoazetidin-1-yl)-4-nitro benzamide Derivatives
Alghamdi, Saad,Almehmadi, Mazen M.,Asif, Mohammad
, p. 91 - 95 (2022/03/27)
A series of N-(3-chloro-2-aryl-4-oxoazetidin-1-yl)-4-nitro benzamide derivatives (4a-g) were synthesized by reacting various N’-arylidene-4-nitro benzo hydrazide (3a-g) with chloro acetyl chloride in the presence of triethylamine and dioxane. Infrared (IR), proton nuclear magnetic resonance (1HNMR), and mass (MS) spectrometric techniques were used to describe the structure of synthesized compounds, which were further tested for in vitro antibacterial activity, and benzylpenicillin was used as a reference drug. Compounds (4b) and (4e) were showed high antibacterial action, whereas the remaining compounds (4a, 4c, 4d, 4f, and 4g) were showed moderate activity. Finally, this research demonstrates the design and development of novel antibacterial agents.
Synthesis of some novel pharmacologically active schiff bases using microwave method and their derivatives formazans by conventional method
Desai, Krunal G.,Desai
, p. 2097 - 2101 (2007/10/03)
Condensation of p-nitrobenzoylhydrazide 1 with substituted aromatic aldehydes 2 under microwave irradiation and by conventional method provide Schiff bases 3a-j. Schiff bases 3a-j on condensation with diazonium salt of 6-methoxy-2-aminobenzothiazole give formazans 4a-j. This reaction is carried out only by conventional method.
