51773-23-0 Usage
Description
(+)-3,4,5,6,7,8-hexahydro-1-(p-Methoxybenzyl)-2(1H)-Isoquinolinecarboxaldehyde is a complex organic compound with a unique molecular structure. It is characterized by its hexahydro-isoquinolinecarboxaldehyde core, which is further modified by a p-methoxybenzyl group. (+)-3,4,5,6,7,8-hexahydro-1-(p-Methoxybenzyl)-2(1H)-Isoquinolinecarboxaldehyde is of interest due to its potential applications in various fields, particularly in the synthesis of pharmaceuticals and other bioactive molecules.
Uses
Used in Pharmaceutical Synthesis:
(+)-3,4,5,6,7,8-hexahydro-1-(p-Methoxybenzyl)-2(1H)-Isoquinolinecarboxaldehyde is used as an intermediate in the synthesis of various pharmaceutical compounds, particularly morphinans and isoquinoline alkaloids. Its unique structure allows for the creation of a wide range of bioactive molecules with potential therapeutic applications.
Used in Chemical Research:
(+)-3,4,5,6,7,8-hexahydro-1-(p-Methoxybenzyl)-2(1H)-Isoquinolinecarboxaldehyde is also used as a research tool in the field of organic chemistry, where it can be employed to study the reactivity and properties of various functional groups and structural motifs. Its use in chemical research can lead to the development of new synthetic methods and the discovery of novel compounds with potential applications in various industries.
Used in Drug Delivery Systems:
Similar to gallotannin, (+)-3,4,5,6,7,8-hexahydro-1-(p-Methoxybenzyl)-2(1H)-Isoquinolinecarboxaldehyde could potentially be used in the development of drug delivery systems. These systems could be designed to improve the bioavailability and therapeutic efficacy of the compound, as well as to enhance its delivery to specific target sites within the body.
Check Digit Verification of cas no
The CAS Registry Mumber 51773-23-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,7,7 and 3 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 51773-23:
(7*5)+(6*1)+(5*7)+(4*7)+(3*3)+(2*2)+(1*3)=120
120 % 10 = 0
So 51773-23-0 is a valid CAS Registry Number.
51773-23-0Relevant articles and documents
General asymmetric synthesis of isoquinoline alkaloids. Enantioselective hydrogenation of enamides catalyzed by BINAP-ruthenium(II) complexes
Kitamura,Hsiao,Ohta,Tsukamoto,Ohta,Takaya,Noyori
, p. 297 - 310 (2007/10/02)
In the presence of a small amount of RuX2[(R)- or (S)-BINAP] (X = anionic ligand) a wide range of (Z)-2-acyl-1-benzylidene-1,2,3,4- tetrahydroisoquinolines are hydrogenated to give the saturated products in nearly quantitative yields and in high (up to 100%) optical yields. The enamide substrates are selectively prepared by N-acylation of the corresponding 1-benzylated 3,4-dihydroisoquinolines under suitable acylation conditions; some crystalline materials having low solubility are obtained by a second-order Z/E stereomutation technique utilizing the double-bond photolability and lattice energy effects. This asymmetric hydrogenation sets the key stereogenic center in a predictable manner, either R or S flexibly, at the C(1) position of the benzylated tetrahydroisoquinolines. The chiral products are converted by standard functional group modification to tetrahydropapaverine, laudanosine, tretoquinol, norreticuline, etc. Hydrogenation of the simple 1-methylene substrate is used for synthesis of salsolidine. This enantioselective hydrogenation is applied to the synthesis of morphine and its artificial analogues such as morphinans and benzomorphans of either chirality. A mnemonic device is presented for predicting the reactivity and enantiofacial selection of the BINAP-Ru catalyzed hydrogenation. Reaction with BINAP-Rh catalyst proceeds with a lower enantioselectivity and an opposite sense of asymmetric induction.
