51776-33-1 Usage
Description
H-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2 is a peptide composed of the amino acids serine, tyrosine, glycine, leucine, arginine, proline, and glycine, with an amidated C-terminus. This specific sequence of amino acids is commonly used in research and pharmaceutical applications due to its potential biological activities and its role in studying protein-protein interactions, enzyme activity, and signal transduction pathways.
Uses
Used in Pharmaceutical Applications:
H-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2 is used as a pharmaceutical agent for its potential biological activities, which may contribute to the development of new therapeutics.
Used in Research:
H-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2 is used as a research tool for studying protein-protein interactions, enzyme activity, and signal transduction pathways, providing valuable insights into various biological processes.
Used in Drug Development:
H-SER-TYR-GLY-LEU-ARG-PRO-GLY-NH2 is used in drug development as a potential lead compound, with its specific amino acid sequence and amidated C-terminus playing a role in its function and potential therapeutic uses.
Check Digit Verification of cas no
The CAS Registry Mumber 51776-33-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,7,7 and 6 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 51776-33:
(7*5)+(6*1)+(5*7)+(4*7)+(3*6)+(2*3)+(1*3)=131
131 % 10 = 1
So 51776-33-1 is a valid CAS Registry Number.
51776-33-1Relevant articles and documents
Hydrolytic cleavage of pyroglutamyl-peptide Bond. V. Selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid
Kobayashi, Junko,Ohki, Kazuhiro,Okimura, Keiko,Hashimoto, Tadashi,Sakura, Naoki
, p. 827 - 831 (2007/10/03)
Application of aqueous methanesulfonic acid (MSA) for selective chemical removal of pyroglutamic acid (pGlu) residue from five biologically active pyroglutamyl-peptides (pGlu-X-peptides, X=amino acid residue at position 2) was examined. Gonadotropin releasing hormone (Gn-RH), dog neuromedin U-8 (d-NMU-8), physalaemin (PH), a bradykinin potentiating peptide (BPP-5a) and neurotensin (NT) as pGlu-X-peptides were incubated in either 70% or 90% aqueous MSA at 25°C. HPLC analysis of the incubation solutions showed that the main decomposition product was H-X-peptide derived from each pGlu-X-peptide by the removal of pGlu. The results revealed that the pGlu-X peptide bond had higher susceptibility than various internal amide bonds in the five peptides examined, including the Trp-Ser bond in Gn-RH, the C-terminal Asn-NH2 in d-NMU-8, and the Asp-Pro bond in PH, whose acid susceptibility is well known. Thus, mild hydrolysis with high concentrations of aqueous MSA may be applicable to chemically selective removal of pGlu from pGlu-X-peptides for structural examinations.
Scheme for the synthesis of luliberin and analogs
Nikolaev, S. V.,Martinov, V. F.
, p. 269 - 270 (2007/10/02)
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