51786-48-2

Basic information

• Product Name: N-(3,5-dimethylphenyl)-N-phenylacetamide
• Synonyms: N-(3,5-dimethylphenyl)-N-phenylacetamide
• CAS NO: 51786-48-2
• Molecular Weight: 239.317
• Mol File: 51786-48-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(3,5-dimethylphenyl)-N-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3,5-dimethylphenyl)-N-phenylacetamide(51786-48-2)
• EPA Substance Registry System: N-(3,5-dimethylphenyl)-N-phenylacetamide(51786-48-2)

Safety Data

• Hazardous Substances Data: 51786-48-2(Hazardous Substances Data)

Upstream product

• 22445-41-6 3,5-dimethylphenyl iodide 
• 103-84-4 Acetanilid 
• 591-50-4 iodobenzene 
• 111-26-2 hexan-1-amine 

Relevant articles and documents

Copper-catalyzed formation of carbon-heteroatom and carbon-carbon bonds

The present invention relates to copper-catalyzed carbon-heteroatom and carbon-carbon bond-forming methods. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of an amide or amine moiety and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In additional embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between a nitrogen atom of an acyl hydrazine and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In other embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-nitrogen bond between the nitrogen atom of a nitrogen-containing heteroaromatic, e.g., indole, pyrazole, and indazole, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. In certain embodiments, the present invention relates to copper-catalyzed methods of forming a carbon-oxygen bond between the oxygen atom of an alcohol and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. The present invention also relates to copper-catalyzed methods of forming a carbon-carbon bond between a reactant comprising a nucleophilic carbon atom, e.g., an enolate or malonate anion, and the activated carbon of an aryl, heteroaryl, or vinyl halide or sulfonate. Importantly, all the methods of the present invention are relatively inexpensive to practice due to the low cost of the copper comprised by the catalysts.

A general and efficient copper catalyst for the amidation of aryl halides and the N-arylation of nitrogen heterocycles [2]

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