51792-36-0

Basic information

• Product Name: CHEMBRDG-BB 5255316
• Synonyms: CHEMBRDG-BB 5255316;5-(1-NAPHTHYL)-2-FURALDEHYDE;UKRORGSYN-BB BBV-5107302;5-(1-naphthyl)-2-furaldehyde(SALTDATA: FREE)
• CAS NO: 51792-36-0
• Molecular Formula: C₁₅H₁₀O₂
• Molecular Weight: 222.24
• Mol File: 51792-36-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 393°C at 760 mmHg
• Flash Point: 123.5°C
• Appearance: /
• Density: 1.212g/cm³
• Vapor Pressure: 2.2E-06mmHg at 25°C
• Refractive Index: 1.66
• CAS DataBase Reference: CHEMBRDG-BB 5255316(CAS DataBase Reference)
• NIST Chemistry Reference: CHEMBRDG-BB 5255316(51792-36-0)
• EPA Substance Registry System: CHEMBRDG-BB 5255316(51792-36-0)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 51792-36-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H10O2/c16-10-12-8-9-15(17-12)14-7-3-5-11-4-1-2-6-13(11)14/h1-10H

Upstream product

• 98-01-1 furfural 
• 134-32-7 1-amino-naphthalene 
• 1899-24-7 5-bromo-2-furancarboxaldehyde 
• 13922-41-3 1-Naphthylboronic acid 
• 99747-74-7 1-naphthyl triflate 
• 90-11-9 1-Bromonaphthalene 

Downstream Products

• 201349-60-2 5-(naphthalen-1-yl)furan-2-carboxylic acid 

Relevant articles and documents

Derivatives of (R)-3-(5-Furanyl)carboxamido-2-aminopropanoic Acid as Potent NMDA Receptor Glycine Site Agonists with GluN2 Subunit-Specific Activity

NMDA receptors mediate glutamatergic neurotransmission and are therapeutic targets due to their involvement in a variety of psychiatric and neurological disorders. Here, we describe the design and synthesis of a series of (R)-3-(5-furanyl)carboxamido-2-am

Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties

A virtual screening campaign aimed at finding structurally new compounds active at 5-HT6R provided a set of candidates. Among those, one structure, 4-(5-{[(2-{5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl}ethyl)amino]methyl}furan-2-yl)phenol (1, 5-HT6R Ki = 91 nM), was selected as a hit for further optimization. As expected, the chemical scaffold of selected compound was significantly different from all the serotonin receptor ligands published to date. Synthetic efforts, supported by molecular modelling, provided 43 compounds representing different substitution patterns. The derivative 42, 4-(5-{[(2-{5-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl}ethyl)amino]methyl}furan-2-yl)phenol (5-HT6R Ki = 25, 5-HT2AR Ki = 32 nM), was selected as a lead and showed a good brain/plasma concentration profile, and it reversed phencyclidine-induced memory impairment. Considering the unique activity profile, the obtained series might be a good starting point for the development of a novel antipsychotic or antidepressant with pro-cognitive properties.

Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3- benzoylphenyl)-3-arylfurylacrylic acid amides

We have designed arylfurylacryl-substituted benzophenones as non-thiol farnesyltransferase inhibitors utilizing a novel aryl binding site of farnesyltransferase. These compounds display activity in the low nanomolar range. We have designed arylfurylacryl-