51796-01-1Relevant articles and documents
Sulfonyl fluoride inhibitors of fatty acid amide hydrolase
Alapafuja, Shakiru O.,Nikas, Spyros P.,Bharathan, Indu T.,Shukla, Vidyanand G.,Nasr, Mahmoud L.,Bowman, Anna L.,Zvonok, Nikolai,Li, Jing,Shi, Xiaomeng,Engen, John R.,Makriyannis, Alexandros
, p. 10074 - 10089 (2013/01/16)
Sulfonyl fluorides are known to inhibit esterases. Early work from our laboratory has identified hexadecyl sulfonylfluoride (AM374) as a potent in vitro and in vivo inhibitor of fatty acid amide hydrolase (FAAH). We now report on later generation sulfonyl
MONOACYLGLYCEROL LIPASE INHIBITORS FOR MODULATION OF CANNABINOID ACTIVITY
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Page/Page column 70, (2009/05/28)
Disclosed are compounds and compositions that inhibit the action of monoacylglycerol lipase (MGL) and fatty acid amide hydrolase (FAAH), methods of inhibiting MGL and FAAH, methods of modulating cannabinoid receptors, and methods of treating various disorders related to the modulation of cannabinoid receptors.