51798-45-9

Basic information

• Product Name: ELASTATINAL
• Synonyms: N-[-N-ALPHA-CARBONYL-CPD-GLN-ALA-AL]-LEU;elastatinal from microbial source;L-2-(2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]glycyl-N1-(1-methyl-2-oxoethyl)-L-glutamamide, stereoisomer;L-Glutamamide, (2S)-2-(4S)-2-amino-1,4,5,6-tetrahydro-4-pyrimidinyl-N-(1S)-1-carboxy-3-methylbutylaminocarbonylglycyl-N1-(1S)-1-methyl-2-oxoethyl-;(2s)-2-[(4s)-2-amino-1,4,5,6-tetrahydro4-pyrimidinyl]-n-[[[(1s)-1-carboxy-3-methylbutyl]amino]carbonyl]glycyl-n1-[(1s)-1-methyl-2-oxoethyl-l-glutamamide;AIDS-006470;Nα-[2-(2-Amino-1,4,5,6-tetrahydropyrimidin-4-yl)-N-[[(1-carboxy-3-methylbutyl)amino]carbonyl]-L-glycyl]-N1-(1-methyl-2-oxoethyl)-L-glutaminamide;Leu-co-cpd-Gln-Ala-h
• CAS NO: 51798-45-9
• Molecular Formula: C21H36N8O6
• Molecular Weight: 496.56
• EINECS: 257-426-7
• Product Categories: Blood Proteins;Plasma &Aldehydes;and Substrates;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C13-C60;Carbonyl Compounds;Cell Biology;Cell Signaling and Neuroscience;Chemical Synthesis;Coagulation Proteins and Reagents;E;Enzyme Inhibitors;Enzyme Inhibitors by Enzyme;Enzymes;Inhibitors;Miscellaneous Peptides;Organic Building Blocks;P to Q;Peptides and Proteins;Peptides for Cell Biology;Plasmin;Protease Inhibitor Specificity Index;Protease Inhibitors;Proteins and Derivatives;Pepetides;peptides
• Mol File: 51798-45-9.mol
• Article Data: 0

Chemical Properties

• Appearance: Yellowish solid
• Density: 1.47 g/cm³
• Refractive Index: 1.635
• Storage Temp.: −20°C
• Solubility: H2O: 20 mg/mL, clear, yellow
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 1 month.
• BRN: 873543
• CAS DataBase Reference: ELASTATINAL(CAS DataBase Reference)
• NIST Chemistry Reference: ELASTATINAL(51798-45-9)
• EPA Substance Registry System: ELASTATINAL(51798-45-9)

Safety Data

• Safety Statements: 22-24/25
• WGK Germany: 3
• RTECS: LZ9600000
• F: 10
• Hazardous Substances Data: 51798-45-9(Hazardous Substances Data)

Usage

Description

Elastatinal, a potent inhibitor of pancreatic elastase, is produced by various species of Actinomycetes. It exhibits a stronger inhibitory effect on pancreatic elastase compared to the leukocyte-derived enzyme. Elastatinal is known to reduce the electrophoretic mobilities of 2A proteinases from poliovirus and human rhinovirus 14 in a dose-dependent manner, suggesting that substrate recognition by 2A proteinases is similar to that of pancreatic elastases. Additionally, it can inhibit elastase-like protease collagenolytic protease from C. maenas digestive glands.

Uses

Used in Pharmaceutical Industry:
Elastatinal is used as an elastase inhibitor for its ability to inhibit pancreatic elastase, which can be beneficial in the development of drugs targeting conditions related to elastase overactivity or imbalance.
Used in Research Applications:
Elastatinal is used as a research tool for studying the function and regulation of pancreatic elastase and other related enzymes. Its inhibitory properties make it a valuable asset in understanding the mechanisms of substrate recognition and enzyme activity in various biological processes.
Used in Diagnostic Applications:
Elastatinal can be employed in diagnostic assays to detect and measure the activity of pancreatic elastase and related enzymes. Its specificity and potency as an inhibitor can help in the accurate assessment of enzyme levels in various samples, contributing to the diagnosis and monitoring of related conditions.

Biochem/physiol Actions

Potent, irreversible elastase inhibitor. Elastatinal is a much stronger inhibitor of elastase from pancreas than from leucocytes.

References

1) Umezawa et al. (1973), Letter: Elastatinal, a new elastase inhibitor produced by actinomycetes; J. Antibiotics, 26 787 2) Nakajima et al. (1992), Identification of elastase as a secretory protease from cultured rat microglia; J. Neurochem., 58 1401 3) Molla et al. (1993), Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteases by elastase-specific inhibitors; J. Virol., 67 4688 4) Menendez-Arias et al. (1992), Isolation and characterization of alpha 2-macroglobulin-protease complexes from purified mouse mammary tumor virus and culture supernatants from virus-infected cell lines; J. Biol. Chem., 267 11392

InChI:InChI=1/C21H36N8O6/c1-11(2)8-13(10-31)26-21(35)29-17(14-6-7-24-20(23)28-14)19(34)27-15(4-5-16(22)32)18(33)25-12(3)9-30/h9-15,17H,4-8H2,1-3H3,(H2,22,32)(H,25,33)(H,27,34)(H3,23,24,28)(H2,26,29,35)/t12-,13-,14-,15-,17-/m0/s1