518-45-6Relevant articles and documents
Copper(II)-Silver(I) Macrocyclic Metal-Organic Framework: A Highly Efficient Reusable Triplet Oxygen Collector and Singlet Oxygen Generator
Wang, Jian-Cheng,Yang, Jing,Wang, Shen-Qing,Ma, Jian-Ping,Dong, Yu-Bin
, p. 1049 - 1052 (2017)
The generation of highly reactive oxygen (1O2) is very significant for a variety of applications such as degradation, bleaching, chemical synthesis, photodynamic therapy for tumor treatment, and others. Herein, we report a novel peroxide-dianion-embedded bimetallic macrocycle, [O22-@Ag4Cu4L4]2+ (2), that can completely release the inserted peroxide dianion as the singlet oxygen (1O2) via a H+-assisted disproportionation process in methanol. Notably, the resulting empty Ag4Cu4L4(ClO4)4 (3) is able to trap oxygen (3O2) from air and fixes it in the macrocycle host as a peroxide dianion; furthermore, it releases it as 1O2 again in the presence of H+. So, the bimetallic macrocycle [Ag4Cu4L4]4+ herein behaves as a highly efficient reusable triplet oxygen receptor and singlet oxygen generator.
Combinatorial discovery of peptide dendrimer enzyme models hydrolyzing isobutyryl fluorescein
Maillard, Noelie,Biswas, Rasomoy,Darbre, Tamis,Reymond, Jean-Louis
, p. 310 - 320 (2011)
Two 6750-membered one-bead-one-compound peptide dendrimer combinatorial libraries L (X4)8(LysX3)4(LysX 2)2LysX1 (X1-4 = 14 different amino acids or deletion, Lys = branching lysine residue) and AcL (with N-terminal acetylation) were prepared by split-and-mix solid phase peptide synthesis. Screening toward fluorogenic substrates for esterase and aldolase activities using the in silica off-bead assay (N. Maillard et al., J. Comb. Chem.2009, 11, 667-675) and bead decoding by amino acid analysis revealed histidine containing sequences active against fluorescein diacetate. Isobutyryl fluorescein, a related hydrophobic fluorogenic substrate, was preferentially hydrolyzed by dendrimers from library AcL containing hydrophobic residues such as AcH3 (AcHis)8(LysLeu)4(LysVal)2LysLysOH, compared to simple oligohistidine peptides as reference catalysts. Polycationic dendrimers from library L with multiple free N-termini such as H8 (His) 8(LysβAla)4(LysThr)2LysaProNH2 (aPro = (2S,4S)-4-aminoproline) showed stronger reactivity toward 8-acetoxypyrene-1,3,6-trisulfonate with partial acylation of N-termini. These experiments highlight the role of noncatalytic amino acids to determine substrate selectivity in peptide dendrimer esterase models.
Peptide dendrimer enzyme models for ester hydrolysis and aldolization prepared by convergent thioether ligation
Uhlich, Nicolas A.,Darbre, Tamis,Reymond, Jean-Louis
, p. 7071 - 7084 (2011)
Peptide dendrimers with multiple histidines or N-terminal prolines efficiently catalyze ester hydrolysis or aldol reactions in aqueous medium. Part of the catalytic proficiency of these dendritic enzyme models stems from multivalency effects observed in G2, G3 and G4 dendrimers displaying multiple catalytic groups in their branches. To study multivalency in higher generation systems, G4, G5 and G6 peptide dendrimers were prepared by a convergent assembly. Thus, peptide dendrimers bearing four or eight chloroacetyl groups at their N-termini underwent multiple thioether ligation with G2 and G3 peptide dendrimers with a cysteine residue at their focal point, to give G4, G5 and G6 dendrimers containing up to 341 amino acids, including multiple histidines or N-terminal prolines. While the efficiency of the esterase catalysts was comparable to that of their lower generation analogs, a remarkable reactivity increase was observed in G5 and G6 aldolase dendrimers.
Controlled initiation of enzymatic reactions in micrometer-sized biomimetic compartments
Karlsson, Anders,Sott, Kristin,Markstr?m, Martin,Davidson, Max,Konkoli, Zoran,Orwar, Owe
, p. 1609 - 1617 (2005)
We present a technique to initiate chemical reactions involving few reactants inside micrometer-scale biomimetic vesicles (10-12 to 10-15 L) integral to three-dimensional surfactant networks. The shape of these networks is under dyna
Fat mass and obesity-associated protein (FTO) inhibitors prepared from 9-(2-carboxyphenyl) xanthene compounds and therapeutic effects thereof
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Paragraph 0055-0058, (2020/07/13)
The invention relates to usage of the following general formula I as a drug for diseases targeting fat mass and obesity-associated protein (FTO), and provides usage of 9-(2-carboxyphenyl) xanthene compounds in preparation of FTO inhibitors. Specifically, the invention discloses usage of the 9-(2-carboxyphenyl) xanthene compounds as shown in the formula (I), as well as derivatives and pharmaceutically acceptable salts thereof, in preparation of the FTO inhibitors or pharmaceutical compositions for treating FTO-related diseases.
Protein Spherical Nucleic Acids for Live-Cell Chemical Analysis
Samanta, Devleena,Ebrahimi, Sasha B.,Kusmierz, Caroline D.,Cheng, Ho Fung,Mirkin, Chad A.
, p. 13350 - 13355 (2020/09/09)
We report the development of a new strategy for the chemical analysis of live cells based on protein spherical nucleic acids (ProSNAs). The ProSNA architecture enables analyte detection via the highly programmable nucleic acid shell or a functional protein core. As a proof-of-concept, we use an i-motif as the nucleic acid recognition element to probe pH in living cells. By interfacing the i-motif with a forced-intercalation readout, we introduce a quencher-free approach that is resistant to false-positive signals, overcoming limitations associated with conventional fluorophore/quencher-based gold NanoFlares. Using glucose oxidase as a functional protein core, we show activity-based, amplified sensing of glucose. This enzymatic system affords greater than 100-fold fluorescence turn on in buffer, is selective for glucose in the presence of close analogs (i.e., glucose-6-phosphate), and can detect glucose above a threshold concentration of ～5 μM, which enables the study of relative changes in intracellular glucose concentrations.
Boronate ester cross-linked PVA hydrogels for the capture and H2O2-mediated release of active fluorophores
Williams, George T.,Sedgwick, Adam C.,Sen, Sajal,Gwynne, Lauren,Gardiner, Jordan E.,Brewster, James T.,Hiscock, Jennifer R.,James, Tony D.,Jenkins, A. Toby A.,Sessler, Jonathan L.
supporting information, p. 5516 - 5519 (2020/06/10)
A new set of PVA hydrogels were formed using the boronate ester fluorescent probe PF1 and the novel boronate fluorescent probe PT1 as the covalent crosslinkers. Treatment with aqueous H2O2 allowed triggered release of the fluorescent dye accompanied by complete dissolution of the hydrogel.
