51804-83-2

Basic information

• Product Name: N,N-Diisopropyl-2-oxo-2-phenyl-acetamide
• Synonyms: N,N-Diisopropyl-2-oxo-2-phenyl-acetamide
• CAS NO: 51804-83-2
• Molecular Weight: 233.31
• Mol File: 51804-83-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N,N-Diisopropyl-2-oxo-2-phenyl-acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Diisopropyl-2-oxo-2-phenyl-acetamide(51804-83-2)
• EPA Substance Registry System: N,N-Diisopropyl-2-oxo-2-phenyl-acetamide(51804-83-2)

Safety Data

• Hazardous Substances Data: 51804-83-2(Hazardous Substances Data)

Upstream product

• 2700-30-3 N,N-diisorpopylformamide 
• 93-89-0 benzoic acid ethyl ester 
• 100-52-7 benzaldehyde 
• 116858-82-3 (N,N-diisopropylcarbamoyl)(trimethyl)stannane 
• 34251-46-2 N,N-diisopropylphenylacetamide 
• 19009-39-3 N,N-diisopropylcarbamoyl chloride 
• 98-88-4 benzoyl chloride 
• 108-18-9 diisopropylamine 
• 98-86-2 acetophenone 
• 25726-04-9 phenylglyoxylyl chloride 

Downstream Products

• 64201-09-8 3-isopropyl-2,2-dimethyl-5-phenyl-oxazolidin-4-one 
• 64201-03-2 3-hydroxy-1-isopropyl-4,4-dimethyl-3-phenyl-azetidin-2-one 
• 4358-87-6 (RS)-methyl mandelate 
• 71910-59-3 2-hydroxy-N-isopropyl-2-phenylacetamide 
• 51804-81-0 α-hydroxy-N,N-bis(1-methylethyl)benzeneacetamide 
• 113791-29-0 (+)-3-hydroxy-1-isopropyl-4,4-dimethyl-3-phenylazetidin-2-one 
• 2019-71-8 N,N-dimethyl-2-phenyl-2-hydroxyacetamide 
• 611-71-2 MANDELIC ACID 
• 64201-03-2 3-hydroxy-1-isopropyl-4,4-dimethyl-3-phenylazetidin-2-one 
• 64201-03-2 3-Hydroxy-1-isopropyl-4,4-dimethyl-3-phenyl-azetidin-2-one 

Relevant articles and documents

Pd(OAc)2-Catalyzed Asymmetric Hydrogenation of α-Iminoesters

An efficient Pd(OAc)2-catalyzed asymmetric hydrogenation of α-iminoesters was realized for the first time at 1 atm hydrogen pressure and room temperature. Pd(OAc)2, a less expensive Pd salt with low toxicity, was found to be the most suitable catalyst precursor rather than Pd(TFA)2 which is usually the catalyst of choice for homogeneous asymmetric hydrogenation. The chiral α-arylglycine fragments are widely found in many chiral products and bioactive molecules.

Generation and Reaction of Carbamoyl Anions in Flow: Applications in the Three-Component Synthesis of Functionalized α-Ketoamides

Using a flow microreactor system, carbamoyllithium compounds were successfully generated and used for reactions with electrophiles to give various amides, including α-ketoamides. The present method could be applied to the three-component synthesis of functionalized α-ketoamides using a carbamoyllithium compound, methyl chloroformate, and a functionalized organolithium reagent. Go with the flow: Using a flow microreactor system, carbamoyllithium compounds were successfully generated and used to react with electrophiles to give various amides, including α-ketoamides. The method was applied to the three-component synthesis of functionalized α-ketoamides using a carbamoyllithium compound, methyl chloroformate, and a functionalized organolithium reagent. PMB=p-methoxybenzyl; FG=functional group.

Reactions of a Carbamoylstannane with Acid Chlorides: Highly Efficient Synthesis of α-Oxo Amides

Treatment of acid chlorides with a carbamoylstannane under mild conditions (mostly rt for a few hours) affords α-oxo amides in high yields. Vicinal polycarbonyl compounds are also obtained, although spontaneous decarbonylation occasionally occurs.